
                                SEQUENCE LISTING

<110> Agensys, Inc.
      Kanner, Steven B.
      Jakobovits, Aya
      Challit-Eid, Pia M.
      Wangmao, Ge
      Raitano, Arthur B.

<120> Nucleic Acids and Corresponding Proteins Entitled 58P1D12 Useful in
      Treatment and Detection of Cancer
  
<130> 511582002047

<140> Not Yet Assigned
<141> Filed Herewith

<160> 83

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 427
<212> DNA
<213> Homo sapiens

<400> 1
cagaattaca aaattctgga accaagtcaa tgagttatta tacttccatg ccactttctt 60
ttctggtact ctttgaaatc cacagtgtag actggtttgg actagttttt gttcttcctt 120
tacttttatg cagcatctgg aaacaacagg ttccaaaagc aaccagtatc agtaagagca 180
ggggtattgt tggtataaca acataaatta gattgggaat tatacctgct tcagtaacaa 240
ccacattctg atgggtgtct cctggttgat ttgtaagata aggcttttct acaggggctg 300
ttggattaat ctctggttca tacttgcaaa tataattgtg cttcatgtta cacctgtcat 360
cattccactg gtaaaggtag ggacccccaa ggccaggatt ggcagttggt tggtgatcat 420
cacaaca                                                           427

<210> 2
<211> 2550
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS            
<222> (380)...(1201)

<400> 2
atccaggacc agggcgcacc ggctcagcct ctcacttgtc agaggccggg gaagagaagc 60
aaagcgcaac ggtgtggtcc aagccggggc ttctgcttcg cctctaggac atacacggga 120
ccccctaact tcagtccccc aaacgcgcac cctcgaagtc ttgaactcca gccccgcaca 180
tccacgcgcg gcacaggcgc ggcaggcggc aggtcccggc cgaaggcgat gcgcgcaggg 240
ggtcgggcag ctgggctcgg gcggcgggag tagggcccgg cagggaggca gggaggctgc 300
agagtcagag tcgcgggctg cgccctgggc agaggccgcc ctcgctccac gcaacacctg 360
ctgctgccac cgcgccgcg atg agc cgc gtg gtc tcg ctg ctg ctg ggc gcc  412
                     Met Ser Arg Val Val Ser Leu Leu Leu Gly Ala
                      1               5                   10
 
gcg ctg ctc tgc ggc cac gga gcc ttc tgc cgc cgc gtg gtc agc ggc   460
Ala Leu Leu Cys Gly His Gly Ala Phe Cys Arg Arg Val Val Ser Gly
             15                  20                  25
 
caa aag gtg tgt ttt gct gac ttc aag cat ccc tgc tac aaa atg gcc   508
Gln Lys Val Cys Phe Ala Asp Phe Lys His Pro Cys Tyr Lys Met Ala
         30                  35                  40
 
tac ttc cat gaa ctg tcc agc cga gtg agc ttt cag gag gca cgc ctg   556
Tyr Phe His Glu Leu Ser Ser Arg Val Ser Phe Gln Glu Ala Arg Leu
     45                  50                  55
 
gct tgt gag agt gag gga gga gtc ctc ctc agc ctt gag aat gaa gca   604
Ala Cys Glu Ser Glu Gly Gly Val Leu Leu Ser Leu Glu Asn Glu Ala
 60                  65                  70                  75
 
gaa cag aag tta ata gag agc atg ttg caa aac ctg aca aaa ccc ggg   652
Glu Gln Lys Leu Ile Glu Ser Met Leu Gln Asn Leu Thr Lys Pro Gly
                 80                  85                  90
 
aca ggg att tct gat ggt gat ttc tgg ata ggg ctt tgg agg aat gga   700
Thr Gly Ile Ser Asp Gly Asp Phe Trp Ile Gly Leu Trp Arg Asn Gly
             95                 100                 105
 
gat ggg caa aca tct ggt gcc tgc cca gat ctc tac cag tgg tct gat   748
Asp Gly Gln Thr Ser Gly Ala Cys Pro Asp Leu Tyr Gln Trp Ser Asp
        110                 115                 120
 
gga agc aat tcc cag tac cga aac tgg tac aca gat gaa cct tcc tgc   796
Gly Ser Asn Ser Gln Tyr Arg Asn Trp Tyr Thr Asp Glu Pro Ser Cys
    125                 130                 135
 
gga agt gaa aag tgt gtt gtg atg tat cac caa cca act gcc aat cct   844
Gly Ser Glu Lys Cys Val Val Met Tyr His Gln Pro Thr Ala Asn Pro
140                 145                 150                 155
 
ggc ctt ggg ggt ccc tac ctt tac cag tgg aat gat gac agg tgt aac   892
Gly Leu Gly Gly Pro Tyr Leu Tyr Gln Trp Asn Asp Asp Arg Cys Asn
                160                 165                 170
 
atg aag cac aat tat att tgc aag tat gaa cca gag att aat cca aca   940
Met Lys His Asn Tyr Ile Cys Lys Tyr Glu Pro Glu Ile Asn Pro Thr
            175                 180                 185
 
gcc cct gta gaa aag cct tat ctt aca aat caa cca gga gac acc cat   988
Ala Pro Val Glu Lys Pro Tyr Leu Thr Asn Gln Pro Gly Asp Thr His
        190                 195                 200
 
cag aat gtg gtt gtt act gaa gca ggt ata att ccc aat cta att tat   1036
Gln Asn Val Val Val Thr Glu Ala Gly Ile Ile Pro Asn Leu Ile Tyr
    205                 210                 215
 
gtt gtt ata cca aca ata ccc ctg ctc tta ctg ata ctg gtt gct ttt   1084
Val Val Ile Pro Thr Ile Pro Leu Leu Leu Leu Ile Leu Val Ala Phe
220                 225                 230                 235
 
gga acc tgt tgt ttc cag atg ctg cat aaa agt aaa gga aga aca aaa   1132
Gly Thr Cys Cys Phe Gln Met Leu His Lys Ser Lys Gly Arg Thr Lys
                240                 245                 250
 
act agt cca aac cag tct aca ctg tgg att tca aag agt acc aga aaa   1180
Thr Ser Pro Asn Gln Ser Thr Leu Trp Ile Ser Lys Ser Thr Arg Lys
            255                 260                 265
 
gaa agt ggc atg gaa gta taa taactcattg acttggttcc agaattttgt      1231
Glu Ser Gly Met Glu Val  *
        270
 
aattctggat ctgtataagg aatggcatca gaacaatagc ttggaatggc ttgaaatcac 1291
aaaggatctg caagatgaac tgtaagctcc cccttgaggc aaatattaaa gtaattttta 1351
tatgtctatt atttcattta aagaatatgc tgtgctaata atggagtgag acatgcttat 1411
tttgctaaag gatgcaccca aacttcaaac ttcaagcaaa tgaaatggac aatgcagata 1471
aagttgttat caacacgtcg ggagtatgtg tgttagaagc aattcctttt atttctttca 1531
cctttcataa gttgttatct agtcaatgta atgtatattg tattgaaatt tacagtgtgc 1591
aaaagtattt tacctttgca taagtgtttg ataaaaatga actgttctaa tatttatttt 1651
tatggcatct catttttcaa tacatgctct tttgattaaa gaaacttatt actgttgtca 1711
actgaattca cacacacaca aatatagtac catagaaaaa gtttgttttc tcgaaataat 1771
tcatctttca gcttctctgc ttttggtcaa tgtctaggaa atctcttcag aaataagaag 1831
ctatttcatt aagtgtgata taaacctcct caaacatttt acttagaggc aaggattgtc 1891
taatttcaat tgtgcaagac atgtgcctta taattatttt tagcttaaaa ttaaacagat 1951
tttgtaataa tgtaactttg ttaataggtg cataaacact aatgcagtca atttgaacaa 2011
aagaagtgac atacacaata taaatcatat gtcttcacac gttgcctata taatgagaag 2071
cagctctctg agggttctga aatcaatgtg gtccctctct tgcccactaa acaaagatgg 2131
ttgttcgggg tttgggattg acactggagg cagatagttg caaagttagt ctaaggtttc 2191
cctagctgta tttagcctct gactatatta gtatacaaag aggtcatgtg gttgagacca 2251
ggtgaatagt cactatcagt gtggagacaa gcacagcaca cagacatttt aggaaggaaa 2311
ggaactacga aatcgtgtga aaatgggttg gaacccatca gtgatcgcat attcattgat 2371
gagggtttgc ttgagataga aaatggtggc tcctttctgt cttatctcct agtttcttca 2431
atgcttacgc cttgttcttc tcaagagaaa gttgtaactc tctggtcttc atatgtccct 2491
gtgctccttt taaccaaata aagagttctt gtttctgaag aaaaaaaaaa aaaaaaaaa  2550

<210> 3
<211> 273
<212> PRT
<213> Homo sapiens

<400> 3
Met Ser Arg Val Val Ser Leu Leu Leu Gly Ala Ala Leu Leu Cys Gly
 1               5                  10                  15      
His Gly Ala Phe Cys Arg Arg Val Val Ser Gly Gln Lys Val Cys Phe
            20                  25                  30          
Ala Asp Phe Lys His Pro Cys Tyr Lys Met Ala Tyr Phe His Glu Leu
        35                  40                  45              
Ser Ser Arg Val Ser Phe Gln Glu Ala Arg Leu Ala Cys Glu Ser Glu
    50                  55                  60                  
Gly Gly Val Leu Leu Ser Leu Glu Asn Glu Ala Glu Gln Lys Leu Ile
65                  70                  75                  80  
Glu Ser Met Leu Gln Asn Leu Thr Lys Pro Gly Thr Gly Ile Ser Asp
                85                  90                  95      
Gly Asp Phe Trp Ile Gly Leu Trp Arg Asn Gly Asp Gly Gln Thr Ser
            100                 105                 110         
Gly Ala Cys Pro Asp Leu Tyr Gln Trp Ser Asp Gly Ser Asn Ser Gln
        115                 120                 125             
Tyr Arg Asn Trp Tyr Thr Asp Glu Pro Ser Cys Gly Ser Glu Lys Cys
    130                 135                 140                 
Val Val Met Tyr His Gln Pro Thr Ala Asn Pro Gly Leu Gly Gly Pro
145                 150                 155                 160 
Tyr Leu Tyr Gln Trp Asn Asp Asp Arg Cys Asn Met Lys His Asn Tyr
                165                 170                 175     
Ile Cys Lys Tyr Glu Pro Glu Ile Asn Pro Thr Ala Pro Val Glu Lys
            180                 185                 190         
Pro Tyr Leu Thr Asn Gln Pro Gly Asp Thr His Gln Asn Val Val Val
        195                 200                 205             
Thr Glu Ala Gly Ile Ile Pro Asn Leu Ile Tyr Val Val Ile Pro Thr
    210                 215                 220                 
Ile Pro Leu Leu Leu Leu Ile Leu Val Ala Phe Gly Thr Cys Cys Phe
225                 230                 235                 240 
Gln Met Leu His Lys Ser Lys Gly Arg Thr Lys Thr Ser Pro Asn Gln
                245                 250                 255     
Ser Thr Leu Trp Ile Ser Lys Ser Thr Arg Lys Glu Ser Gly Met Glu

            260                 265                 270         
Val
    


<210> 4
<211> 2418
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS            
<222> (388)...(1086)

<400> 4
ctgtggtgtt tttcccccgc tcctctggct gccttcctga tggatctctg tggtcccagg 60
caggaatggc ctgcttgggg acccagcgag ctcccaaggc ctttcctgct gcttcctcta 120
tccctgtgtt ttgcttggct ctctaaattg actcagctcc aggacatcag gaccccaggt 180
tctctggtct tgggactctg agacttgcac caggaatcct gcccaggctc tcaggccttt 240
ggactcagac tgagctactt cactggcttt cctggttctc cagcttgaag atggcagatc 300
gtgggacttc tcagcctcca taattgagtg agccaattcc ctggccaaaa ggtgtgtttt 360
gctgacttca agcatccctg ctacaaa atg gcc tac ttc cat gaa ctg tcc agc 414
                              Met Ala Tyr Phe His Glu Leu Ser Ser
                               1               5
 
cga gtg agc ttt cag gag gca cgc ctg gct tgt gag agt gag gga gga   462
Arg Val Ser Phe Gln Glu Ala Arg Leu Ala Cys Glu Ser Glu Gly Gly
 10                  15                  20                  25
 
gtc ctc ctc agc ctt gag aat gaa gca gaa cag aag tta ata gag agc   510
Val Leu Leu Ser Leu Glu Asn Glu Ala Glu Gln Lys Leu Ile Glu Ser
                 30                  35                  40
 
atg ttg caa aac ctg aca aaa ccc ggg aca ggg att tct gat ggt gat   558
Met Leu Gln Asn Leu Thr Lys Pro Gly Thr Gly Ile Ser Asp Gly Asp
             45                  50                  55
 
ttc tgg ata ggg ctt tgg agg aat gga gat ggg caa aca tct ggt gcc   606
Phe Trp Ile Gly Leu Trp Arg Asn Gly Asp Gly Gln Thr Ser Gly Ala
         60                  65                  70
 
tgc cca gat ctc tac cag tgg tct gat gga agc aat tcc cag tac cga   654
Cys Pro Asp Leu Tyr Gln Trp Ser Asp Gly Ser Asn Ser Gln Tyr Arg
     75                  80                  85

 
aac tgg tac aca gat gaa cct tcc tgc gga agt gaa aag tgt gtt gtg   702
Asn Trp Tyr Thr Asp Glu Pro Ser Cys Gly Ser Glu Lys Cys Val Val
 90                  95                 100                 105
 
atg tat cac caa cca act gcc aat cct ggc ctt ggg ggt ccc tac ctt   750
Met Tyr His Gln Pro Thr Ala Asn Pro Gly Leu Gly Gly Pro Tyr Leu
                110                 115                 120
 
tac cag tgg aat gat gac agg tgt aac atg aag cac aat tat att tgc   798
Tyr Gln Trp Asn Asp Asp Arg Cys Asn Met Lys His Asn Tyr Ile Cys
            125                 130                 135
 
aag tat gaa cca gag att aat cca aca gcc cct gta gaa aag cct tat   846
Lys Tyr Glu Pro Glu Ile Asn Pro Thr Ala Pro Val Glu Lys Pro Tyr
        140                 145                 150
 
ctt aca aat caa cca gga gac acc cat cag aat gtg gtt gtt act gaa   894
Leu Thr Asn Gln Pro Gly Asp Thr His Gln Asn Val Val Val Thr Glu
    155                 160                 165
 
gca ggt ata att ccc aat cta att tat gtt gtt ata cca aca ata ccc   942
Ala Gly Ile Ile Pro Asn Leu Ile Tyr Val Val Ile Pro Thr Ile Pro
170                 175                 180                 185
 
ctg ctc tta ctg ata ctg gtt gct ttt gga acc tgt tgt ttc cag atg   990
Leu Leu Leu Leu Ile Leu Val Ala Phe Gly Thr Cys Cys Phe Gln Met
                190                 195                 200
 
ctg cat aaa agt aaa gga aga aca aaa act agt cca aac cag tct aca   1038
Leu His Lys Ser Lys Gly Arg Thr Lys Thr Ser Pro Asn Gln Ser Thr
            205                 210                 215
 
ctg tgg att tca aag agt acc aga aaa gaa agt ggc atg gaa gta taa   1086
Leu Trp Ile Ser Lys Ser Thr Arg Lys Glu Ser Gly Met Glu Val  *
        220                 225                 230
 
taactcattg acttggttcc agaattttgt aattctggat ctgtataagg aatggcatca 1146
gaacaatagc ttggaatggc ttgaaatcac aaaggatctg caagatgaac tgtaagctcc 1206
cccttgaggc aaatattaaa gtaattttta tatgtctatt atttcattta aagaatatgc 1266
tgtgctaata atggagtgag acatgcttat tttgctaaag gatgcaccca aacttcaaac 1326
ttcaagcaaa tgaaatggac aatgcagata aagttgttat caacacgtcg ggagtatgtg 1386
tgttagaagc aattcctttt atttctttca cctttcataa gttgttatct agtcaatgta 1446
atgtatattg tattgaaatt tacagtgtgc aaaagtattt tacctttgca taagtgtttg 1506
ataaaaatga actgttctaa tatttatttt tatggcatct catttttcaa tacatgctct 1566
tttgattaaa gaaacttatt actgttgtca actgaattca cacacacaca aatatagtac 1626
catagaaaaa gtttgttttc tcgaaataat tcatctttca gcttctctgc ttttggtcaa 1686
tgtctaggaa atctcttcag aaataagaag ctatttcatt aagtgtgata taaacctcct 1746
caaacatttt acttagaggc aaggattgtc taatttcaat tgtgcaagac atgtgcctta 1806
taattatttt tagcttaaaa ttaaacagat tttgtaataa tgtaactttg ttaataggtg 1866
cataaacact aatgcagtca atttgaacaa aagaagtgac atacacaata taaatcatat 1926
gtcttcacac gttgcctata taatgagaag cagctctctg agggttctga aatcaatgtg 1986
gtccctctct tgcccactaa acaaagatgg ttgttcgggg tttgggattg acactggagg 2046
cagatagttg caaagttagt ctaaggtttc cctagctgta tttagcctct gactatatta 2106
gtatacaaag aggtcatgtg gttgagacca ggtgaatagt cactatcagt gtggagacaa 2166

gcacagcaca cagacatttt aggaaggaaa ggaactacga aatcgtgtga aaatgggttg 2226
gaacccatca gtgatcgcat attcattgat gagggtttgc ttgagataga aaatggtggc 2286
tcctttctgt cttatctcct agtttcttca atgcttacgc cttgttcttc tcaagagaaa 2346
gttgtaactc tctggtcttc atatgtccct gtgctccttt taaccaaata aagagttctt 2406
gtttctgaag aa                                                     2418

<210> 5
<211> 232
<212> PRT
<213> Homo sapiens

<400> 5
Met Ala Tyr Phe His Glu Leu Ser Ser Arg Val Ser Phe Gln Glu Ala
 1               5                  10                  15      
Arg Leu Ala Cys Glu Ser Glu Gly Gly Val Leu Leu Ser Leu Glu Asn
            20                  25                  30          
Glu Ala Glu Gln Lys Leu Ile Glu Ser Met Leu Gln Asn Leu Thr Lys
        35                  40                  45              
Pro Gly Thr Gly Ile Ser Asp Gly Asp Phe Trp Ile Gly Leu Trp Arg
    50                  55                  60                  
Asn Gly Asp Gly Gln Thr Ser Gly Ala Cys Pro Asp Leu Tyr Gln Trp
65                  70                  75                  80  
Ser Asp Gly Ser Asn Ser Gln Tyr Arg Asn Trp Tyr Thr Asp Glu Pro
                85                  90                  95      
Ser Cys Gly Ser Glu Lys Cys Val Val Met Tyr His Gln Pro Thr Ala
            100                 105                 110         
Asn Pro Gly Leu Gly Gly Pro Tyr Leu Tyr Gln Trp Asn Asp Asp Arg
        115                 120                 125             
Cys Asn Met Lys His Asn Tyr Ile Cys Lys Tyr Glu Pro Glu Ile Asn
    130                 135                 140                 
Pro Thr Ala Pro Val Glu Lys Pro Tyr Leu Thr Asn Gln Pro Gly Asp
145                 150                 155                 160 
Thr His Gln Asn Val Val Val Thr Glu Ala Gly Ile Ile Pro Asn Leu
                165                 170                 175     
Ile Tyr Val Val Ile Pro Thr Ile Pro Leu Leu Leu Leu Ile Leu Val
            180                 185                 190         
Ala Phe Gly Thr Cys Cys Phe Gln Met Leu His Lys Ser Lys Gly Arg
        195                 200                 205             
Thr Lys Thr Ser Pro Asn Gln Ser Thr Leu Trp Ile Ser Lys Ser Thr
    210                 215                 220                 
Arg Lys Glu Ser Gly Met Glu Val
225                 230         


<210> 6
<211> 2236
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS            
<222> (206)...(904)

<400> 6
gcttgaagat ggcagatcgt gggacttctc agcctccata attgagtgag ccaattccct 60
gaatacaaca agaagatggc catctgtaga ccaggaggtg gtccctcccc agaaactgga 120
tgggccagca cgttgattct gagcttctag cctccagaac tgccaaaagg tgtgttttgc 180
tgacttcaag catccctgct acaaa atg gcc tac ttc cat gaa ctg tcc agc   232
                            Met Ala Tyr Phe His Glu Leu Ser Ser
                             1               5
 
cga gtg agc ttt cag gag gca cgc ctg gct tgt gag agt gag gga gga   280
Arg Val Ser Phe Gln Glu Ala Arg Leu Ala Cys Glu Ser Glu Gly Gly
 10                  15                  20                  25
 
gtc ctc ctc agc ctt gag aat gaa gca gaa cag aag tta ata gag agc   328
Val Leu Leu Ser Leu Glu Asn Glu Ala Glu Gln Lys Leu Ile Glu Ser
                 30                  35                  40
 
atg ttg caa aac ctg aca aaa ccc ggg aca ggg att tct gat ggt gat   376
Met Leu Gln Asn Leu Thr Lys Pro Gly Thr Gly Ile Ser Asp Gly Asp
             45                  50                  55
 
ttc tgg ata ggg ctt tgg agg aat gga gat ggg caa aca tct ggt gcc   424
Phe Trp Ile Gly Leu Trp Arg Asn Gly Asp Gly Gln Thr Ser Gly Ala
         60                  65                  70
 
tgc cca gat ctc tac cag tgg tct gat gga agc aat tcc cag tac cga   472
Cys Pro Asp Leu Tyr Gln Trp Ser Asp Gly Ser Asn Ser Gln Tyr Arg
     75                  80                  85
 
aac tgg tac aca gat gaa cct tcc tgc gga agt gaa aag tgt gtt gtg   520
Asn Trp Tyr Thr Asp Glu Pro Ser Cys Gly Ser Glu Lys Cys Val Val
 90                  95                 100                 105
 
atg tat cac caa cca act gcc aat cct ggc ctt ggg ggt ccc tac ctt   568
Met Tyr His Gln Pro Thr Ala Asn Pro Gly Leu Gly Gly Pro Tyr Leu
                110                 115                 120
 
tac cag tgg aat gat gac agg tgt aac atg aag cac aat tat att tgc   616
Tyr Gln Trp Asn Asp Asp Arg Cys Asn Met Lys His Asn Tyr Ile Cys
            125                 130                 135
 
aag tat gaa cca gag att aat cca aca gcc cct gta gaa aag cct tat   664
Lys Tyr Glu Pro Glu Ile Asn Pro Thr Ala Pro Val Glu Lys Pro Tyr
        140                 145                 150
 
ctt aca aat caa cca gga gac acc cat cag aat gtg gtt gtt act gaa   712
Leu Thr Asn Gln Pro Gly Asp Thr His Gln Asn Val Val Val Thr Glu
    155                 160                 165
 
gca ggt ata att ccc aat cta att tat gtt gtt ata cca aca ata ccc   760
Ala Gly Ile Ile Pro Asn Leu Ile Tyr Val Val Ile Pro Thr Ile Pro
170                 175                 180                 185
 
ctg ctc tta ctg ata ctg gtt gct ttt gga acc tgt tgt ttc cag atg   808
Leu Leu Leu Leu Ile Leu Val Ala Phe Gly Thr Cys Cys Phe Gln Met
                190                 195                 200
 
ctg cat aaa agt aaa gga aga aca aaa act agt cca aac cag tct aca   856
Leu His Lys Ser Lys Gly Arg Thr Lys Thr Ser Pro Asn Gln Ser Thr
            205                 210                 215
 
ctg tgg att tca aag agt acc aga aaa gaa agt ggc atg gaa gta taa   904
Leu Trp Ile Ser Lys Ser Thr Arg Lys Glu Ser Gly Met Glu Val  *
        220                 225                 230
 
taactcattg acttggttcc agaattttgt aattctggat ctgtataagg aatggcatca 964
gaacaatagc ttggaatggc ttgaaatcac aaaggatctg caagatgaac tgtaagctcc 1024
cccttgaggc aaatattaaa gtaattttta tatgtctatt atttcattta aagaatatgc 1084
tgtgctaata atggagtgag acatgcttat tttgctaaag gatgcaccca aacttcaaac 1144
ttcaagcaaa tgaaatggac aatgcagata aagttgttat caacacgtcg ggagtatgtg 1204
tgttagaagc aattcctttt atttctttca cctttcataa gttgttatct agtcaatgta 1264
atgtatattg tattgaaatt tacagtgtgc aaaagtattt tacctttgca taagtgtttg 1324
ataaaaatga actgttctaa tatttatttt tatggcatct catttttcaa tacatgctct 1384
tttgattaaa gaaacttatt actgttgtca actgaattca cacacacaca aatatagtac 1444
catagaaaaa gtttgttttc tcgaaataat tcatctttca gcttctctgc ttttggtcaa 1504
tgtctaggaa atctcttcag aaataagaag ctatttcatt aagtgtgata taaacctcct 1564
caaacatttt acttagaggc aaggattgtc taatttcaat tgtgcaagac atgtgcctta 1624
taattatttt tagcttaaaa ttaaacagat tttgtaataa tgtaactttg ttaataggtg 1684
cataaacact aatgcagtca atttgaacaa aagaagtgac atacacaata taaatcatat 1744
gtcttcacac gttgcctata taatgagaag cagctctctg agggttctga aatcaatgtg 1804
gtccctctct tgcccactaa acaaagatgg ttgttcgggg tttgggattg acactggagg 1864
cagatagttg caaagttagt ctaaggtttc cctagctgta tttagcctct gactatatta 1924
gtatacaaag aggtcatgtg gttgagacca ggtgaatagt cactatcagt gtggagacaa 1984
gcacagcaca cagacatttt aggaaggaaa ggaactacga aatcgtgtga aaatgggttg 2044
gaacccatca gtgatcgcat attcattgat gagggtttgc ttgagataga aaatggtggc 2104
tcctttctgt cttatctcct agtttcttca atgcttacgc cttgttcttc tcaagagaaa 2164
gttgtaactc tctggtcttc atatgtccct gtgctccttt taaccaaata aagagttctt 2224
gtttctgaag aa                                                     2236

<210> 7
<211> 232
<212> PRT
<213> Homo sapiens

<400> 7
Met Ala Tyr Phe His Glu Leu Ser Ser Arg Val Ser Phe Gln Glu Ala
 1               5                  10                  15      
Arg Leu Ala Cys Glu Ser Glu Gly Gly Val Leu Leu Ser Leu Glu Asn
            20                  25                  30          
Glu Ala Glu Gln Lys Leu Ile Glu Ser Met Leu Gln Asn Leu Thr Lys
        35                  40                  45              
Pro Gly Thr Gly Ile Ser Asp Gly Asp Phe Trp Ile Gly Leu Trp Arg
    50                  55                  60                  
Asn Gly Asp Gly Gln Thr Ser Gly Ala Cys Pro Asp Leu Tyr Gln Trp
65                  70                  75                  80  
Ser Asp Gly Ser Asn Ser Gln Tyr Arg Asn Trp Tyr Thr Asp Glu Pro
                85                  90                  95      
Ser Cys Gly Ser Glu Lys Cys Val Val Met Tyr His Gln Pro Thr Ala
            100                 105                 110         
Asn Pro Gly Leu Gly Gly Pro Tyr Leu Tyr Gln Trp Asn Asp Asp Arg
        115                 120                 125             
Cys Asn Met Lys His Asn Tyr Ile Cys Lys Tyr Glu Pro Glu Ile Asn
    130                 135                 140                 
Pro Thr Ala Pro Val Glu Lys Pro Tyr Leu Thr Asn Gln Pro Gly Asp
145                 150                 155                 160 
Thr His Gln Asn Val Val Val Thr Glu Ala Gly Ile Ile Pro Asn Leu
                165                 170                 175     
Ile Tyr Val Val Ile Pro Thr Ile Pro Leu Leu Leu Leu Ile Leu Val
            180                 185                 190         
Ala Phe Gly Thr Cys Cys Phe Gln Met Leu His Lys Ser Lys Gly Arg
        195                 200                 205             
Thr Lys Thr Ser Pro Asn Gln Ser Thr Leu Trp Ile Ser Lys Ser Thr
    210                 215                 220                 
Arg Lys Glu Ser Gly Met Glu Val
225                 230         



<210> 8
<211> 2133
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS            
<222> (206)...(916)

<400> 8
gcttgaagat ggcagatcgt gggacttctc agcctccata attgagtgag ccaattccct 60
gaatacaaca agaagatggc catctgtaga ccaggaggtg gtccctcccc agaaactgga 120
tgggccagca cgttgattct gagcttctag cctccagaac tgccaaaagg tgtgttttgc 180
tgacttcaag catccctgct acaaa atg gcc tac ttc cat gaa ctg tcc agc   232
                            Met Ala Tyr Phe His Glu Leu Ser Ser
                             1               5
 
cga gtg agc ttt cag gag gca cgc ctg gct tgt gag agt gag gga gga   280
Arg Val Ser Phe Gln Glu Ala Arg Leu Ala Cys Glu Ser Glu Gly Gly
 10                  15                  20                  25
 
gtc ctc ctc agc ctt gag aat gaa gca gaa cag aag tta ata gag agc   328
Val Leu Leu Ser Leu Glu Asn Glu Ala Glu Gln Lys Leu Ile Glu Ser
                 30                  35                  40
 
atg ttg caa aac ctg aca aaa ccc ggg aca ggg att tct gat ggt gat   376
Met Leu Gln Asn Leu Thr Lys Pro Gly Thr Gly Ile Ser Asp Gly Asp
             45                  50                  55
 
ttc tgg ata ggg ctt tgg agg aat gga gat ggg caa aca tct ggt gcc   424
Phe Trp Ile Gly Leu Trp Arg Asn Gly Asp Gly Gln Thr Ser Gly Ala
         60                  65                  70
 
tgc cca gat ctc tac cag tgg tct gat gga agc aat tcc cag tac cga   472
Cys Pro Asp Leu Tyr Gln Trp Ser Asp Gly Ser Asn Ser Gln Tyr Arg
     75                  80                  85
 
aac tgg tac aca gat gaa cct tcc tgc gga agt gaa aag tgt gtt gtg   520
Asn Trp Tyr Thr Asp Glu Pro Ser Cys Gly Ser Glu Lys Cys Val Val
 90                  95                 100                 105
 
atg tat cac caa cca act gcc aat cct ggc ctt ggg ggt ccc tac ctt   568
Met Tyr His Gln Pro Thr Ala Asn Pro Gly Leu Gly Gly Pro Tyr Leu
                110                 115                 120
 
tac cag tgg aat gat gac agg tgt aac atg aag cac aat tat att tgc   616
Tyr Gln Trp Asn Asp Asp Arg Cys Asn Met Lys His Asn Tyr Ile Cys
            125                 130                 135
 
aag tat gaa cca gag att aat cca aca gcc cct gta gaa aag cct tat   664
Lys Tyr Glu Pro Glu Ile Asn Pro Thr Ala Pro Val Glu Lys Pro Tyr
        140                 145                 150
 
ctt aca aat caa cca gga gac acc cat cag aat gtg gtt gtt act gaa   712
Leu Thr Asn Gln Pro Gly Asp Thr His Gln Asn Val Val Val Thr Glu
    155                 160                 165
 
gca gta aag gaa gaa caa aaa cta gtc caa acc agt cta cac tgt gga   760
Ala Val Lys Glu Glu Gln Lys Leu Val Gln Thr Ser Leu His Cys Gly
170                 175                 180                 185
 
ttt caa aga gta cca gaa aag aaa gtg gca tgg aag tat aat aac tca   808
Phe Gln Arg Val Pro Glu Lys Lys Val Ala Trp Lys Tyr Asn Asn Ser
                190                 195                 200
 
ttg act tgg ttc cag aat ttt gta att ctg gat ctg tat aag gaa tgg   856
Leu Thr Trp Phe Gln Asn Phe Val Ile Leu Asp Leu Tyr Lys Glu Trp
            205                 210                 215
 
cat cag aac aat agc ttg gaa tgg ctt gaa atc aca aag gat ctg caa   904
His Gln Asn Asn Ser Leu Glu Trp Leu Glu Ile Thr Lys Asp Leu Gln
        220                 225                 230
 
gat gaa ctg taa gctccccctt gaggcaaata ttaaagtaat ttttatatgt       956
Asp Glu Leu  *
    235
 
ctattatttc atttaaagaa tatgctgtgc taataatgga gtgagacatg cttattttgc 1016
taaaggatgc acccaaactt caaacttcaa gcaaatgaaa tggacaatgc agataaagtt 1076
gttatcaaca cgtcgggagt atgtgtgtta gaagcaattc cttttatttc tttcaccttt 1136
cataagttgt tatctagtca atgtaatgta tattgtattg aaatttacag tgtgcaaaag 1196
tattttacct ttgcataagt gtttgataaa aatgaactgt tctaatattt atttttatgg 1256
catctcattt ttcaatacat gctcttttga ttaaagaaac ttattactgt tgtcaactga 1316
attcacacac acacaaatat agtaccatag aaaaagtttg ttttctcgaa ataattcatc 1376
tttcagcttc tctgcttttg gtcaatgtct aggaaatctc ttcagaaata agaagctatt 1436
tcattaagtg tgatataaac ctcctcaaac attttactta gaggcaagga ttgtctaatt 1496
tcaattgtgc aagacatgtg ccttataatt atttttagct taaaattaaa cagattttgt 1556
aataatgtaa ctttgttaat aggtgcataa acactaatgc agtcaatttg aacaaaagaa 1616
gtgacataca caatataaat catatgtctt cacacgttgc ctatataatg agaagcagct 1676
ctctgagggt tctgaaatca atgtggtccc tctcttgccc actaaacaaa gatggttgtt 1736
cggggtttgg gattgacact ggaggcagat agttgcaaag ttagtctaag gtttccctag 1796
ctgtatttag cctctgacta tattagtata caaagaggtc atgtggttga gaccaggtga 1856
atagtcacta tcagtgtgga gacaagcaca gcacacagac attttaggaa ggaaaggaac 1916
tacgaaatcg tgtgaaaatg ggttggaacc catcagtgat cgcatattca ttgatgaggg 1976
tttgcttgag atagaaaatg gtggctcctt tctgtcttat ctcctagttt cttcaatgct 2036
tacgccttgt tcttctcaag agaaagttgt aactctctgg tcttcatatg tccctgtgct 2096
ccttttaacc aaataaagag ttcttgtttc tgaagaa                          2133

<210> 9
<211> 236
<212> PRT
<213> Homo sapiens


<400> 9
Met Ala Tyr Phe His Glu Leu Ser Ser Arg Val Ser Phe Gln Glu Ala
 1               5                  10                  15      
Arg Leu Ala Cys Glu Ser Glu Gly Gly Val Leu Leu Ser Leu Glu Asn
            20                  25                  30          
Glu Ala Glu Gln Lys Leu Ile Glu Ser Met Leu Gln Asn Leu Thr Lys
        35                  40                  45              
Pro Gly Thr Gly Ile Ser Asp Gly Asp Phe Trp Ile Gly Leu Trp Arg
    50                  55                  60                  
Asn Gly Asp Gly Gln Thr Ser Gly Ala Cys Pro Asp Leu Tyr Gln Trp
65                  70                  75                  80  
Ser Asp Gly Ser Asn Ser Gln Tyr Arg Asn Trp Tyr Thr Asp Glu Pro
                85                  90                  95      
Ser Cys Gly Ser Glu Lys Cys Val Val Met Tyr His Gln Pro Thr Ala
            100                 105                 110         
Asn Pro Gly Leu Gly Gly Pro Tyr Leu Tyr Gln Trp Asn Asp Asp Arg
        115                 120                 125             
Cys Asn Met Lys His Asn Tyr Ile Cys Lys Tyr Glu Pro Glu Ile Asn
    130                 135                 140                 
Pro Thr Ala Pro Val Glu Lys Pro Tyr Leu Thr Asn Gln Pro Gly Asp
145                 150                 155                 160 
Thr His Gln Asn Val Val Val Thr Glu Ala Val Lys Glu Glu Gln Lys
                165                 170                 175     
Leu Val Gln Thr Ser Leu His Cys Gly Phe Gln Arg Val Pro Glu Lys
            180                 185                 190         
Lys Val Ala Trp Lys Tyr Asn Asn Ser Leu Thr Trp Phe Gln Asn Phe
        195                 200                 205             
Val Ile Leu Asp Leu Tyr Lys Glu Trp His Gln Asn Asn Ser Leu Glu
    210                 215                 220                 
Trp Leu Glu Ile Thr Lys Asp Leu Gln Asp Glu Leu
225                 230                 235     


<210> 10
<211> 2033
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS            
<222> (106)...(816)

<400> 10
gcttgaagat ggcagatcgt gggacttctc agcctccata attgagtgag ccaattccct 60
ggccaaaagg tgtgttttgc tgacttcaag catccctgct acaaa atg gcc tac ttc 117
                                                  Met Ala Tyr Phe
                                                   1
 
cat gaa ctg tcc agc cga gtg agc ttt cag gag gca cgc ctg gct tgt   165
His Glu Leu Ser Ser Arg Val Ser Phe Gln Glu Ala Arg Leu Ala Cys
 5                   10                  15                  20
 
gag agt gag gga gga gtc ctc ctc agc ctt gag aat gaa gca gaa cag   213
Glu Ser Glu Gly Gly Val Leu Leu Ser Leu Glu Asn Glu Ala Glu Gln
                 25                  30                  35
 
aag tta ata gag agc atg ttg caa aac ctg aca aaa ccc ggg aca ggg   261
Lys Leu Ile Glu Ser Met Leu Gln Asn Leu Thr Lys Pro Gly Thr Gly
             40                  45                  50
 
att tct gat ggt gat ttc tgg ata ggg ctt tgg agg aat gga gat ggg   309
Ile Ser Asp Gly Asp Phe Trp Ile Gly Leu Trp Arg Asn Gly Asp Gly
         55                  60                  65
 
caa aca tct ggt gcc tgc cca gat ctc tac cag tgg tct gat gga agc   357
Gln Thr Ser Gly Ala Cys Pro Asp Leu Tyr Gln Trp Ser Asp Gly Ser
     70                  75                  80
 
aat tcc cag tac cga aac tgg tac aca gat gaa cct tcc tgc gga agt   405
Asn Ser Gln Tyr Arg Asn Trp Tyr Thr Asp Glu Pro Ser Cys Gly Ser
 85                  90                  95                 100
 
gaa aag tgt gtt gtg atg tat cac caa cca act gcc aat cct ggc ctt   453
Glu Lys Cys Val Val Met Tyr His Gln Pro Thr Ala Asn Pro Gly Leu
                105                 110                 115
 
ggg ggt ccc tac ctt tac cag tgg aat gat gac agg tgt aac atg aag   501
Gly Gly Pro Tyr Leu Tyr Gln Trp Asn Asp Asp Arg Cys Asn Met Lys
            120                 125                 130
 
cac aat tat att tgc aag tat gaa cca gag att aat cca aca gcc cct   549
His Asn Tyr Ile Cys Lys Tyr Glu Pro Glu Ile Asn Pro Thr Ala Pro
        135                 140                 145
 
gta gaa aag cct tat ctt aca aat caa cca gga gac acc cat cag aat   597
Val Glu Lys Pro Tyr Leu Thr Asn Gln Pro Gly Asp Thr His Gln Asn
    150                 155                 160
 
gtg gtt gtt act gaa gca gta aag gaa gaa caa aaa cta gtc caa acc   645
Val Val Val Thr Glu Ala Val Lys Glu Glu Gln Lys Leu Val Gln Thr
165                 170                 175                 180
 
agt cta cac tgt gga ttt caa aga gta cca gaa aag aaa gtg gca tgg   693
Ser Leu His Cys Gly Phe Gln Arg Val Pro Glu Lys Lys Val Ala Trp
                185                 190                 195
 
aag tat aat aac tca ttg act tgg ttc cag aat ttt gta att ctg gat   741
Lys Tyr Asn Asn Ser Leu Thr Trp Phe Gln Asn Phe Val Ile Leu Asp
            200                 205                 210
 
ctg tat aag gaa tgg cat cag aac aat agc ttg gaa tgg ctt gaa atc   789
Leu Tyr Lys Glu Trp His Gln Asn Asn Ser Leu Glu Trp Leu Glu Ile
        215                 220                 225
 
aca aag gat ctg caa gat gaa ctg taa gctccccctt gaggcaaata         836
Thr Lys Asp Leu Gln Asp Glu Leu  *
    230                 235
 
ttaaagtaat ttttatatgt ctattatttc atttaaagaa tatgctgtgc taataatgga 896
gtgagacatg cttattttgc taaaggatgc acccaaactt caaacttcaa gcaaatgaaa 956
tggacaatgc agataaagtt gttatcaaca cgtcgggagt atgtgtgtta gaagcaattc 1016
cttttatttc tttcaccttt cataagttgt tatctagtca atgtaatgta tattgtattg 1076
aaatttacag tgtgcaaaag tattttacct ttgcataagt gtttgataaa aatgaactgt 1136
tctaatattt atttttatgg catctcattt ttcaatacat gctcttttga ttaaagaaac 1196
ttattactgt tgtcaactga attcacacac acacaaatat agtaccatag aaaaagtttg 1256
ttttctcgaa ataattcatc tttcagcttc tctgcttttg gtcaatgtct aggaaatctc 1316
ttcagaaata agaagctatt tcattaagtg tgatataaac ctcctcaaac attttactta 1376
gaggcaagga ttgtctaatt tcaattgtgc aagacatgtg ccttataatt atttttagct 1436
taaaattaaa cagattttgt aataatgtaa ctttgttaat aggtgcataa acactaatgc 1496
agtcaatttg aacaaaagaa gtgacataca caatataaat catatgtctt cacacgttgc 1556
ctatataatg agaagcagct ctctgagggt tctgaaatca atgtggtccc tctcttgccc 1616
actaaacaaa gatggttgtt cggggtttgg gattgacact ggaggcagat agttgcaaag 1676
ttagtctaag gtttccctag ctgtatttag cctctgacta tattagtata caaagaggtc 1736
atgtggttga gaccaggtga atagtcacta tcagtgtgga gacaagcaca gcacacagac 1796
attttaggaa ggaaaggaac tacgaaatcg tgtgaaaatg ggttggaacc catcagtgat 1856
cgcatattca ttgatgaggg tttgcttgag atagaaaatg gtggctcctt tctgtcttat 1916
ctcctagttt cttcaatgct tacgccttgt tcttctcaag agaaagttgt aactctctgg 1976
tcttcatatg tccctgtgct ccttttaacc aaataaagag ttcttgtttc tgaagaa    2033

<210> 11
<211> 236
<212> PRT
<213> Homo sapiens

<400> 11
Met Ala Tyr Phe His Glu Leu Ser Ser Arg Val Ser Phe Gln Glu Ala
 1               5                  10                  15      
Arg Leu Ala Cys Glu Ser Glu Gly Gly Val Leu Leu Ser Leu Glu Asn
            20                  25                  30          
Glu Ala Glu Gln Lys Leu Ile Glu Ser Met Leu Gln Asn Leu Thr Lys
        35                  40                  45              
Pro Gly Thr Gly Ile Ser Asp Gly Asp Phe Trp Ile Gly Leu Trp Arg
    50                  55                  60                  
Asn Gly Asp Gly Gln Thr Ser Gly Ala Cys Pro Asp Leu Tyr Gln Trp
65                  70                  75                  80  
Ser Asp Gly Ser Asn Ser Gln Tyr Arg Asn Trp Tyr Thr Asp Glu Pro
                85                  90                  95      
Ser Cys Gly Ser Glu Lys Cys Val Val Met Tyr His Gln Pro Thr Ala
            100                 105                 110         
Asn Pro Gly Leu Gly Gly Pro Tyr Leu Tyr Gln Trp Asn Asp Asp Arg
        115                 120                 125             
Cys Asn Met Lys His Asn Tyr Ile Cys Lys Tyr Glu Pro Glu Ile Asn
    130                 135                 140                 
Pro Thr Ala Pro Val Glu Lys Pro Tyr Leu Thr Asn Gln Pro Gly Asp
145                 150                 155                 160 
Thr His Gln Asn Val Val Val Thr Glu Ala Val Lys Glu Glu Gln Lys
                165                 170                 175     
Leu Val Gln Thr Ser Leu His Cys Gly Phe Gln Arg Val Pro Glu Lys
            180                 185                 190         
Lys Val Ala Trp Lys Tyr Asn Asn Ser Leu Thr Trp Phe Gln Asn Phe
        195                 200                 205             
Val Ile Leu Asp Leu Tyr Lys Glu Trp His Gln Asn Asn Ser Leu Glu
    210                 215                 220                 
Trp Leu Glu Ile Thr Lys Asp Leu Gln Asp Glu Leu
225                 230                 235     


<210> 12
<211> 273
<212> PRT
<213> Homo sapiens

<400> 12
Met Ser Arg Val Val Ser Leu Leu Leu Gly Ala Ala Leu Leu Cys Gly
 1               5                  10                  15      
His Gly Ala Phe Cys Arg Arg Val Val Ser Gly Gln Lys Val Cys Phe
            20                  25                  30          
Ala Asp Phe Lys His Pro Cys Tyr Lys Met Ala Tyr Phe His Glu Leu
        35                  40                  45              
Ser Ser Arg Val Ser Phe Gln Glu Ala Arg Leu Ala Cys Glu Ser Glu
    50                  55                  60                  
Gly Gly Val Leu Leu Ser Leu Glu Asn Glu Ala Glu Gln Lys Leu Ile
65                  70                  75                  80  
Glu Ser Met Leu Gln Asn Leu Thr Lys Pro Gly Thr Gly Ile Ser Asp
                85                  90                  95      
Gly Asp Phe Trp Ile Gly Leu Trp Arg Asn Gly Asp Gly Gln Thr Ser
            100                 105                 110         
Gly Ala Cys Pro Asp Leu Tyr Gln Trp Ser Asp Gly Ser Asn Ser Gln
        115                 120                 125             
Tyr Arg Asn Trp Tyr Thr Asp Glu Pro Ser Cys Gly Ser Glu Lys Cys
    130                 135                 140                 
Val Val Met Tyr His Gln Pro Thr Ala Asn Pro Gly Leu Gly Gly Pro
145                 150                 155                 160 
Tyr Leu Tyr Gln Trp Asn Asp Asp Arg Cys Asn Met Lys His Asn Tyr
                165                 170                 175     
Ile Cys Lys Tyr Glu Pro Glu Ile Asn Pro Thr Ala Pro Val Glu Lys
            180                 185                 190         
Pro Tyr Leu Thr Asn Gln Pro Gly Asp Thr His Gln Asn Val Val Val
        195                 200                 205             
Thr Glu Ala Gly Ile Ile Pro Asn Leu Ile Tyr Val Val Ile Pro Thr

    210                 215                 220                 
Ile Pro Leu Leu Leu Leu Ile Leu Val Ala Phe Gly Thr Cys Cys Phe
225                 230                 235                 240 
Gln Met Leu His Lys Ser Lys Gly Arg Thr Lys Thr Ser Pro Asn Gln
                245                 250                 255     
Ser Thr Leu Trp Ile Ser Lys Ser Thr Arg Lys Glu Ser Gly Met Glu
            260                 265                 270         
Val
    


<210> 13
<211> 232
<212> PRT
<213> Homo sapiens

<400> 13
Met Ala Tyr Phe His Glu Leu Ser Ser Arg Val Ser Phe Gln Glu Ala
 1               5                  10                  15      
Arg Leu Ala Cys Glu Ser Glu Gly Gly Val Leu Leu Ser Leu Glu Asn
            20                  25                  30          
Glu Ala Glu Gln Lys Leu Ile Glu Ser Met Leu Gln Asn Leu Thr Lys
        35                  40                  45              
Pro Gly Thr Gly Ile Ser Asp Gly Asp Phe Trp Ile Gly Leu Trp Arg
    50                  55                  60                  
Asn Gly Asp Gly Gln Thr Ser Gly Ala Cys Pro Asp Leu Tyr Gln Trp
65                  70                  75                  80  
Ser Asp Gly Ser Asn Ser Gln Tyr Arg Asn Trp Tyr Thr Asp Glu Pro
                85                  90                  95      
Ser Cys Gly Ser Glu Lys Cys Val Val Met Tyr His Gln Pro Thr Ala
            100                 105                 110         
Asn Pro Gly Leu Gly Gly Pro Tyr Leu Tyr Gln Trp Asn Asp Asp Arg
        115                 120                 125             
Cys Asn Met Lys His Asn Tyr Ile Cys Lys Tyr Glu Pro Glu Ile Asn
    130                 135                 140                 
Pro Thr Ala Pro Val Glu Lys Pro Tyr Leu Thr Asn Gln Pro Gly Asp
145                 150                 155                 160 
Thr His Gln Asn Val Val Val Thr Glu Ala Gly Ile Ile Pro Asn Leu
                165                 170                 175     
Ile Tyr Val Val Ile Pro Thr Ile Pro Leu Leu Leu Leu Ile Leu Val
            180                 185                 190         
Ala Phe Gly Thr Cys Cys Phe Gln Met Leu His Lys Ser Lys Gly Arg
        195                 200                 205             
Thr Lys Thr Ser Pro Asn Gln Ser Thr Leu Trp Ile Ser Lys Ser Thr
    210                 215                 220                 
Arg Lys Glu Ser Gly Met Glu Val
225                 230         


<210> 14
<211> 236
<212> PRT
<213> Homo sapiens

<400> 14
Met Ala Tyr Phe His Glu Leu Ser Ser Arg Val Ser Phe Gln Glu Ala
 1               5                  10                  15      
Arg Leu Ala Cys Glu Ser Glu Gly Gly Val Leu Leu Ser Leu Glu Asn
            20                  25                  30          
Glu Ala Glu Gln Lys Leu Ile Glu Ser Met Leu Gln Asn Leu Thr Lys
        35                  40                  45              
Pro Gly Thr Gly Ile Ser Asp Gly Asp Phe Trp Ile Gly Leu Trp Arg
    50                  55                  60                  
Asn Gly Asp Gly Gln Thr Ser Gly Ala Cys Pro Asp Leu Tyr Gln Trp
65                  70                  75                  80  
Ser Asp Gly Ser Asn Ser Gln Tyr Arg Asn Trp Tyr Thr Asp Glu Pro
                85                  90                  95      
Ser Cys Gly Ser Glu Lys Cys Val Val Met Tyr His Gln Pro Thr Ala
            100                 105                 110         
Asn Pro Gly Leu Gly Gly Pro Tyr Leu Tyr Gln Trp Asn Asp Asp Arg
        115                 120                 125             
Cys Asn Met Lys His Asn Tyr Ile Cys Lys Tyr Glu Pro Glu Ile Asn
    130                 135                 140                 
Pro Thr Ala Pro Val Glu Lys Pro Tyr Leu Thr Asn Gln Pro Gly Asp
145                 150                 155                 160 
Thr His Gln Asn Val Val Val Thr Glu Ala Val Lys Glu Glu Gln Lys
                165                 170                 175     
Leu Val Gln Thr Ser Leu His Cys Gly Phe Gln Arg Val Pro Glu Lys
            180                 185                 190         
Lys Val Ala Trp Lys Tyr Asn Asn Ser Leu Thr Trp Phe Gln Asn Phe
        195                 200                 205             
Val Ile Leu Asp Leu Tyr Lys Glu Trp His Gln Asn Asn Ser Leu Glu
    210                 215                 220                 
Trp Leu Glu Ile Thr Lys Asp Leu Gln Asp Glu Leu
225                 230                 235     


<210> 15
<211> 273
<212> PRT
<213> Homo sapiens

<400> 15
Met Ser Arg Val Val Ser Leu Leu Leu Gly Ala Ala Leu Leu Cys Gly
 1               5                  10                  15      
His Gly Ala Phe Cys Arg Arg Val Val Ser Gly Gln Lys Val Cys Phe
            20                  25                  30          
Ala Asp Phe Lys His Pro Cys Tyr Lys Met Ala Tyr Phe His Glu Leu
        35                  40                  45              
Ser Ser Arg Val Ser Phe Gln Glu Ala Arg Leu Ala Cys Glu Ser Glu
    50                  55                  60                  
Gly Gly Val Leu Leu Ser Leu Glu Asn Glu Ala Glu Gln Lys Leu Ile
65                  70                  75                  80  
Glu Ser Met Leu Gln Asn Leu Thr Lys Pro Gly Thr Gly Ile Ser Asp
                85                  90                  95      
Gly Asp Phe Trp Ile Gly Leu Trp Arg Asn Gly Asp Gly Gln Thr Ser
            100                 105                 110         
Gly Ala Cys Pro Asp Leu Tyr Gln Trp Ser Asp Gly Ser Asn Ser Gln
        115                 120                 125             
Tyr Arg Asn Trp Tyr Thr Asp Glu Pro Ser Cys Gly Ser Glu Lys Cys
    130                 135                 140                 
Val Val Met Tyr His Gln Pro Thr Ala Asn Pro Gly Leu Gly Gly Pro
145                 150                 155                 160 
Tyr Leu Tyr Gln Trp Asn Asp Asp Arg Cys Asn Met Lys His Asn Tyr
                165                 170                 175     
Ile Cys Lys Tyr Glu Pro Glu Ile Asn Pro Thr Ala Pro Val Glu Lys
            180                 185                 190         
Pro Tyr Leu Thr Asn Gln Pro Gly Asp Thr His Gln Asn Val Val Val
        195                 200                 205             
Thr Glu Ala Gly Ile Ile Pro Asn Leu Ile Tyr Val Val Ile Pro Thr
    210                 215                 220                 
Ile Pro Leu Leu Leu Leu Ile Leu Val Ala Phe Gly Thr Cys Cys Phe
225                 230                 235                 240 
Gln Met Leu His Lys Ser Lys Gly Arg Thr Lys Thr Ser Pro Asn Gln
                245                 250                 255     
Ser Thr Leu Trp Ile Ser Lys Ser Thr Arg Lys Glu Ser Gly Met Glu
            260                 265                 270         
Val
    


<210> 16
<211> 232
<212> PRT
<213> Homo sapiens

<400> 16
Met Ala Tyr Phe His Glu Leu Ser Ser Arg Val Ser Phe Gln Glu Ala
 1               5                  10                  15      
Arg Leu Ala Cys Glu Ser Glu Gly Gly Val Leu Leu Ser Leu Glu Asn
            20                  25                  30          
Glu Ala Glu Gln Lys Leu Ile Glu Ser Met Leu Gln Asn Leu Thr Lys
        35                  40                  45              
Pro Gly Thr Gly Ile Ser Asp Gly Asp Phe Trp Ile Gly Leu Trp Arg
    50                  55                  60                  
Asn Gly Asp Gly Gln Thr Ser Gly Ala Cys Pro Asp Leu Tyr Gln Trp
65                  70                  75                  80  
Ser Asp Gly Ser Asn Ser Gln Tyr Arg Asn Trp Tyr Thr Asp Glu Pro
                85                  90                  95      
Ser Cys Gly Ser Glu Lys Cys Val Val Met Tyr His Gln Pro Thr Ala
            100                 105                 110         
Asn Pro Gly Leu Gly Gly Pro Tyr Leu Tyr Gln Trp Asn Asp Asp Arg
        115                 120                 125             
Cys Asn Met Lys His Asn Tyr Ile Cys Lys Tyr Glu Pro Glu Ile Asn
    130                 135                 140                 
Pro Thr Ala Pro Val Glu Lys Pro Tyr Leu Thr Asn Gln Pro Gly Asp
145                 150                 155                 160 
Thr His Gln Asn Val Val Val Thr Glu Ala Gly Ile Ile Pro Asn Leu
                165                 170                 175     
Ile Tyr Val Val Ile Pro Thr Ile Pro Leu Leu Leu Leu Ile Leu Val
            180                 185                 190         
Ala Phe Gly Thr Cys Cys Phe Gln Met Leu His Lys Ser Lys Gly Arg
        195                 200                 205             
Thr Lys Thr Ser Pro Asn Gln Ser Thr Leu Trp Ile Ser Lys Ser Thr
    210                 215                 220                 
Arg Lys Glu Ser Gly Met Glu Val
225                 230         


<210> 17
<211> 236
<212> PRT
<213> Homo sapiens

<400> 17
Met Ala Tyr Phe His Glu Leu Ser Ser Arg Val Ser Phe Gln Glu Ala
 1               5                  10                  15      
Arg Leu Ala Cys Glu Ser Glu Gly Gly Val Leu Leu Ser Leu Glu Asn
            20                  25                  30          
Glu Ala Glu Gln Lys Leu Ile Glu Ser Met Leu Gln Asn Leu Thr Lys
        35                  40                  45              
Pro Gly Thr Gly Ile Ser Asp Gly Asp Phe Trp Ile Gly Leu Trp Arg
    50                  55                  60                  
Asn Gly Asp Gly Gln Thr Ser Gly Ala Cys Pro Asp Leu Tyr Gln Trp
65                  70                  75                  80  
Ser Asp Gly Ser Asn Ser Gln Tyr Arg Asn Trp Tyr Thr Asp Glu Pro
                85                  90                  95      
Ser Cys Gly Ser Glu Lys Cys Val Val Met Tyr His Gln Pro Thr Ala
            100                 105                 110         
Asn Pro Gly Leu Gly Gly Pro Tyr Leu Tyr Gln Trp Asn Asp Asp Arg
        115                 120                 125             
Cys Asn Met Lys His Asn Tyr Ile Cys Lys Tyr Glu Pro Glu Ile Asn
    130                 135                 140                 
Pro Thr Ala Pro Val Glu Lys Pro Tyr Leu Thr Asn Gln Pro Gly Asp
145                 150                 155                 160 
Thr His Gln Asn Val Val Val Thr Glu Ala Val Lys Glu Glu Gln Lys
                165                 170                 175     
Leu Val Gln Thr Ser Leu His Cys Gly Phe Gln Arg Val Pro Glu Lys
            180                 185                 190         
Lys Val Ala Trp Lys Tyr Asn Asn Ser Leu Thr Trp Phe Gln Asn Phe
        195                 200                 205             
Val Ile Leu Asp Leu Tyr Lys Glu Trp His Gln Asn Asn Ser Leu Glu
    210                 215                 220                 
Trp Leu Glu Ile Thr Lys Asp Leu Gln Asp Glu Leu
225                 230                 235     


<210> 18
<211> 14
<212> PRT
<213> Tetanus toxoid

<400> 18
Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu
 1               5                  10                  


<210> 19
<211> 21
<212> PRT
<213> Plasmodium falciparum

<400> 19
Asp Ile Glu Lys Lys Ile Ala Lys Met Glu Lys Ala Ser Ser Val Phe
 1               5                  10                  15      
Asn Val Val Asn Ser
            20      


<210> 20
<211> 16
<212> PRT
<213> Streptococcus

<400> 20
Gly Ala Val Asp Ser Ile Leu Gly Gly Val Ala Thr Tyr Gly Ala Ala
 1               5                  10                  15      


<210> 21
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Pan-DR binding epitope

<221> VARIANT        
<222> 3
<223> Xaa = cyclohexyalanine, phenylalanine, or tyrosine

<221> VARIANT        
<222> 1, 13
<223> Xaa = d-alanine or l-alanine

<400> 21
Xaa Lys Xaa Val Ala Ala Trp Thr Leu Lys Ala Ala Xaa
 1               5                  10              


<210> 22
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer

<400> 22
ttttgatcaa gctt                                                   14

<210> 23
<211> 42
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer

<400> 23
ctaatacgac tcactatagg gctcgagcgg ccgcccgggc ag                    42

<210> 24
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer

<400> 24
gatcctgccc gg                                                     12

<210> 25
<211> 40
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer

<400> 25
gtaatacgac tcactatagg gcagcgtggt cgcggccgag                       40

<210> 26
<211> 10
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer

<400> 26
gatcctcggc                                                        10

<210> 27
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer

<400> 27
ctaatacgac tcactatagg gc                                          22

<210> 28
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer

<400> 28
tcgagcggcc gcccgggcag ga                                          22

<210> 29
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer

<400> 29
agcgtggtcg cggccgagga                                             20

<210> 30
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer

<400> 30
atatcgccgc gctcgtcgtc gacaa                                       25

<210> 31
<211> 26
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer

<400> 31
agccacacgc agctcattgt agaagg                                      26

<210> 32
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer

<400> 32
cctgcttcag taacaaccac attct                                       25

<210> 33
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer

<400> 33
ctttaccagt ggaatgatga cagg                                        24

<210> 34
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> FLAG Tag

<400> 34
gattacaagg atgacgacga taag                                        24

<210> 35
<211> 24
<212> DNA
<213> Homo sapiens

<400> 35
aagggacgaa gacgaacacu uctt                                        24

<210> 36
<211> 23
<212> DNA
<213> Homo sapiens

<400> 36
aactgaagac ctgaagacaa taa                                         23

<210> 37
<211> 4
<212> PRT
<213> Homo sapiens

<400> 37
Asn Leu Thr Lys
 1              


<210> 38
<211> 4
<212> PRT
<213> Homo sapiens

<400> 38
Asn Pro Thr Ala
 1              


<210> 39
<211> 9
<212> PRT
<213> Homo sapiens

<400> 39
Ser Ser Arg Val Ser Phe Gln Glu Ala
 1               5                  


<210> 40
<211> 9
<212> PRT
<213> Homo sapiens

<400> 40
Gly Val Leu Leu Ser Leu Glu Asn Glu
 1               5                  


<210> 41
<211> 9
<212> PRT
<213> Homo sapiens

<400> 41
Gly Thr Gly Ile Ser Asp Gly Asp Phe
 1               5                  


<210> 42
<211> 9
<212> PRT
<213> Homo sapiens

<400> 42
Asp Gly Gln Thr Ser Gly Ala Cys Pro
 1               5                  


<210> 43
<211> 9
<212> PRT
<213> Homo sapiens

<400> 43
Asp Gly Ser Asn Ser Gln Tyr Arg Asn
 1               5                  


<210> 44
<211> 9
<212> PRT
<213> Homo sapiens

<400> 44
Pro Ser Cys Gly Ser Glu Lys Cys Val
 1               5                  


<210> 45
<211> 9
<212> PRT
<213> Homo sapiens

<400> 45
Met Leu His Lys Ser Lys Gly Arg Thr
 1               5                  


<210> 46
<211> 9
<212> PRT
<213> Homo sapiens

<400> 46
Arg Thr Lys Thr Ser Pro Asn Gln Ser
 1               5                  


<210> 47
<211> 9
<212> PRT
<213> Homo sapiens

<400> 47
Thr Arg Lys Glu Ser Gly Met Glu Val
 1               5                  


<210> 48
<211> 9
<212> PRT
<213> Homo sapiens

<400> 48
Ile Ser Lys Ser Thr Arg Lys Glu Ser
 1               5                  


<210> 49
<211> 9
<212> PRT
<213> Homo sapiens

<400> 49
Cys Pro Asp Leu Tyr Gln Trp Ser Asp
 1               5                  


<210> 50
<211> 9
<212> PRT
<213> Homo sapiens

<400> 50
Ser Asn Ser Gln Tyr Arg Asn Trp Tyr
 1               5                  


<210> 51
<211> 9
<212> PRT
<213> Homo sapiens

<400> 51
Tyr Arg Asn Trp Tyr Thr Asp Glu Pro
 1               5                  


<210> 52
<211> 9
<212> PRT
<213> Homo sapiens

<400> 52
Met Lys His Asn Tyr Ile Cys Lys Tyr
 1               5                  


<210> 53
<211> 9
<212> PRT
<213> Homo sapiens

<400> 53
Val Glu Lys Pro Tyr Leu Thr Asn Gln
 1               5                  


<210> 54
<211> 9
<212> PRT
<213> Homo sapiens

<400> 54
Pro Asn Leu Ile Tyr Val Val Ile Pro
 1               5                  


<210> 55
<211> 23
<212> PRT
<213> Homo sapiens

<400> 55
Ser Met Asx Asn Asp Asn Gly Ser Thr Val Cys Phe Ala Asp Phe Lys
 1               5                  10                  15      
His Pro Cys Tyr Lys Met Ala
            20              


<210> 56
<211> 273
<212> PRT
<213> Homo sapiens

<400> 56
Met Ser Arg Val Val Ser Leu Leu Leu Gly Ala Ala Leu Leu Cys Gly
 1               5                  10                  15      
His Gly Ala Phe Cys Arg Arg Val Val Ser Gly Gln Lys Val Cys Phe
            20                  25                  30          
Ala Asp Phe Lys His Pro Cys Tyr Lys Met Ala Tyr Phe His Glu Leu
        35                  40                  45              
Ser Ser Arg Val Ser Phe Gln Glu Ala Arg Leu Ala Cys Glu Ser Glu
    50                  55                  60                  
Gly Gly Val Leu Leu Ser Leu Glu Asn Glu Ala Glu Gln Lys Leu Ile
65                  70                  75                  80  
Glu Ser Met Leu Gln Asn Leu Thr Lys Pro Gly Thr Gly Ile Ser Asp
                85                  90                  95      
Gly Asp Phe Trp Ile Gly Leu Trp Arg Asn Gly Asp Gly Gln Thr Ser
            100                 105                 110         
Gly Ala Cys Pro Asp Leu Tyr Gln Trp Ser Asp Gly Ser Asn Ser Gln
        115                 120                 125             
Tyr Arg Asn Trp Tyr Thr Asp Glu Pro Ser Cys Gly Ser Glu Lys Cys
    130                 135                 140                 
Val Val Met Tyr His Gln Pro Thr Ala Asn Pro Gly Leu Gly Gly Pro
145                 150                 155                 160 
Tyr Leu Tyr Gln Trp Asn Asp Asp Arg Cys Asn Met Lys His Asn Tyr
                165                 170                 175     
Ile Cys Lys Tyr Glu Pro Glu Ile Asn Pro Thr Ala Pro Val Glu Lys
            180                 185                 190         
Pro Tyr Leu Thr Asn Gln Pro Gly Asp Thr His Gln Asn Val Val Val
        195                 200                 205             
Thr Glu Ala Gly Ile Ile Pro Asn Leu Ile Tyr Val Val Ile Pro Thr
    210                 215                 220                 
Ile Pro Leu Leu Leu Leu Ile Leu Val Ala Phe Gly Thr Cys Cys Phe
225                 230                 235                 240 
Gln Met Leu His Lys Ser Lys Gly Arg Thr Lys Thr Ser Pro Asn Gln
                245                 250                 255     
Ser Thr Leu Trp Ile Ser Lys Ser Thr Arg Lys Glu Ser Gly Met Glu
            260                 265                 270         
Val
    


<210> 57
<211> 74
<212> PRT
<213> Homo sapiens

<400> 57
Gln Asn Val Val Val Thr Glu Ala Val Lys Glu Glu Gln Lys Leu Val
 1               5                  10                  15      
Gln Thr Ser Leu His Cys Gly Phe Gln Arg Val Pro Glu Lys Lys Val
            20                  25                  30          
Ala Trp Lys Tyr Asn Asn Ser Leu Thr Trp Phe Gln Asn Phe Val Ile
        35                  40                  45              
Leu Asp Leu Tyr Lys Glu Trp His Gln Asn Asn Ser Leu Glu Trp Leu

    50                  55                  60                  
Glu Ile Thr Lys Asp Leu Gln Asp Glu Leu
65                  70                  


<210> 58
<211> 75
<212> PRT
<213> Homo sapiens

<400> 58
His Gln Asn Val Val Val Thr Glu Ala Val Lys Glu Glu Gln Lys Leu
 1               5                  10                  15      
Val Gln Thr Ser Leu His Cys Gly Phe Gln Arg Val Pro Glu Lys Lys
            20                  25                  30          
Val Ala Trp Lys Tyr Asn Asn Ser Leu Thr Trp Phe Gln Asn Phe Val
        35                  40                  45              
Ile Leu Asp Leu Tyr Lys Glu Trp His Gln Asn Asn Ser Leu Glu Trp
    50                  55                  60                  
Leu Glu Ile Thr Lys Asp Leu Gln Asp Glu Leu
65                  70                  75  


<210> 59
<211> 80
<212> PRT
<213> Homo sapiens

<400> 59
Gln Pro Gly Asp Thr His Gln Asn Val Val Val Thr Glu Ala Val Lys
 1               5                  10                  15      
Glu Glu Gln Lys Leu Val Gln Thr Ser Leu His Cys Gly Phe Gln Arg
            20                  25                  30          
Val Pro Glu Lys Lys Val Ala Trp Lys Tyr Asn Asn Ser Leu Thr Trp
        35                  40                  45              
Phe Gln Asn Phe Val Ile Leu Asp Leu Tyr Lys Glu Trp His Gln Asn
    50                  55                  60                  
Asn Ser Leu Glu Trp Leu Glu Ile Thr Lys Asp Leu Gln Asp Glu Leu
65                  70                  75                  80  


<210> 60
<211> 2418
<212> DNA
<213> Homo sapiens

<400> 60
ctgtggtgtt tttcccccgc tcctctggct gccttcctga tggatctctg tggtcccagg 60
caggaatggc ctgcttgggg acccagcgag ctcccaaggc ctttcctgct gcttcctcta 120
tccctgtgtt ttgcttggct ctctaaattg actcagctcc aggacatcag gaccccaggt 180
tctctggtct tgggactctg agacttgcac caggaatcct gcccaggctc tcaggccttt 240
ggactcagac tgagctactt cactggcttt cctggttctc cagcttgaag atggcagatc 300
gtgggacttc tcagcctcca taattgagtg agccaattcc ctggccaaaa ggtgtgtttt 360
gctgacttca agcatccctg ctacaaaatg gcctacttcc atgaactgtc cagccgagtg 420
agctttcagg aggcacgcct ggcttgtgag agtgagggag gagtcctcct cagccttgag 480
aatgaagcag aacagaagtt aatagagagc atgttgcaaa acctgacaaa acccgggaca 540
gggatttctg atggtgattt ctggataggg ctttggagga atggagatgg gcaaacatct 600
ggtgcctgcc cagatctcta ccagtggtct gatggaagca attcccagta ccgaaactgg 660
tacacagatg aaccttcctg cggaagtgaa aagtgtgttg tgatgtatca ccaaccaact 720
gccaatcctg gccttggggg tccctacctt taccagtgga atgatgacag gtgtaacatg 780
aagcacaatt atatttgcaa gtatgaacca gagattaatc caacagcccc tgtagaaaag 840
ccttatctta caaatcaacc aggagacacc catcagaatg tggttgttac tgaagcaggt 900
ataattccca atctaattta tgttgttata ccaacaatac ccctgctctt actgatactg 960
gttgcttttg gaacctgttg tttccagatg ctgcataaaa gtaaaggaag aacaaaaact 1020
agtccaaacc agtctacact gtggatttca aagagtacca gaaaagaaag tggcatggaa 1080
gtataataac tcattgactt ggttccagaa ttttgtaatt ctggatctgt ataaggaatg 1140
gcatcagaac aatagcttgg aatggcttga aatcacaaag gatctgcaag atgaactgta 1200
agctccccct tgaggcaaat attaaagtaa tttttatatg tctattattt catttaaaga 1260
atatgctgtg ctaataatgg agtgagacat gcttattttg ctaaaggatg cacccaaact 1320
tcaaacttca agcaaatgaa atggacaatg cagataaagt tgttatcaac acgtcgggag 1380
tatgtgtgtt agaagcaatt ccttttattt ctttcacctt tcataagttg ttatctagtc 1440
aatgtaatgt atattgtatt gaaatttaca gtgtgcaaaa gtattttacc tttgcataag 1500
tgtttgataa aaatgaactg ttctaatatt tatttttatg gcatctcatt tttcaataca 1560
tgctcttttg attaaagaaa cttattactg ttgtcaactg aattcacaca cacacaaata 1620
tagtaccata gaaaaagttt gttttctcga aataattcat ctttcagctt ctctgctttt 1680
ggtcaatgtc taggaaatct cttcagaaat aagaagctat ttcattaagt gtgatataaa 1740
cctcctcaaa cattttactt agaggcaagg attgtctaat ttcaattgtg caagacatgt 1800
gccttataat tatttttagc ttaaaattaa acagattttg taataatgta actttgttaa 1860
taggtgcata aacactaatg cagtcaattt gaacaaaaga agtgacatac acaatataaa 1920
tcatatgtct tcacacgttg cctatataat gagaagcagc tctctgaggg ttctgaaatc 1980
aatgtggtcc ctctcttgcc cactaaacaa agatggttgt tcggggtttg ggattgacac 2040
tggaggcaga tagttgcaaa gttagtctaa ggtttcccta gctgtattta gcctctgact 2100
atattagtat acaaagaggt catgtggttg agaccaggtg aatagtcact atcagtgtgg 2160
agacaagcac agcacacaga cattttagga aggaaaggaa ctacgaaatc gtgtgaaaat 2220
gggttggaac ccatcagtga tcgcatattc attgatgagg gtttgcttga gatagaaaat 2280
ggtggctcct ttctgtctta tctcctagtt tcttcaatgc ttacgccttg ttcttctcaa 2340
gagaaagttg taactctctg gtcttcatat gtccctgtgc tccttttaac caaataaaga 2400
gttcttgttt ctgaagaa                                               2418

<210> 61
<211> 2076
<212> DNA
<213> Homo sapiens

<400> 61
ggccaaaagg tgtgttttgc tgacttcaag catccctgct acaaaatggc ctacttccat 60
gaactgtcca gccgagtgag ctttcaggag gcacgcctgg cttgtgagag tgagggagga 120
gtcctcctca gccttgagaa tgaagcagaa cagaagttaa tagagagcat gttgcaaaac 180
ctgacaaaac ccgggacagg gatttctgat ggtgatttct ggatagggct ttggaggaat 240
ggagatgggc aaacatctgg tgcctgccca gatctctacc agtggtctga tggaagcaat 300
tcccagtacc gaaactggta cacagatgaa ccttcctgcg gaagtgaaaa gtgtgttgtg 360
atgtatcacc aaccaactgc caatcctggc cttgggggtc cctaccttta ccagtggaat 420

gatgacaggt gtaacatgaa gcacaattat atttgcaagt atgaaccaga gattaatcca 480
acagcccctg tagaaaagcc ttatcttaca aatcaaccag gagacaccca tcagaatgtg 540
gttgttactg aagcaggtat aattcccaat ctaatttatg ttgttatacc aacaataccc 600
ctgctcttac tgatactggt tgcttttgga acctgttgtt tccagatgct gcataaaagt 660
aaaggaagaa caaaaactag tccaaaccag tctacactgt ggatttcaaa gagtaccaga 720
aaagaaagtg gcatggaagt ataataactc attgacttgg ttccagaatt ttgtaattct 780
ggatctgtat aaggaatggc atcagaacaa tagcttggaa tggcttgaaa tcacaaagga 840
tctgcaagat gaactgtaag ctcccccttg aggcaaatat taaagtaatt tttatatgtc 900
tattatttca tttaaagaat atgctgtgct aataatggag tgagacatgc ttattttgct 960
aaaggatgca cccaaacttc aaacttcaag caaatgaaat ggacaatgca gataaagttg 1020
ttatcaacac gtcgggagta tgtgtgttag aagcaattcc ttttatttct ttcacctttc 1080
ataagttgtt atctagtcaa tgtaatgtat attgtattga aatttacagt gtgcaaaagt 1140
attttacctt tgcataagtg tttgataaaa atgaactgtt ctaatattta tttttatggc 1200
atctcatttt tcaatacatg ctcttttgat taaagaaact tattactgtt gtcaactgaa 1260
ttcacacaca cacaaatata gtaccataga aaaagtttgt tttctcgaaa taattcatct 1320
ttcagcttct ctgcttttgg tcaatgtcta ggaaatctct tcagaaataa gaagctattt 1380
cattaagtgt gatataaacc tcctcaaaca ttttacttag aggcaaggat tgtctaattt 1440
caattgtgca agacatgtgc cttataatta tttttagctt aaaattaaac agattttgta 1500
ataatgtaac tttgttaata ggtgcataaa cactaatgca gtcaatttga acaaaagaag 1560
tgacatacac aatataaatc atatgtcttc acacgttgcc tatataatga gaagcagctc 1620
tctgagggtt ctgaaatcaa tgtggtccct ctcttgccca ctaaacaaag atggttgttc 1680
ggggtttggg attgacactg gaggcagata gttgcaaagt tagtctaagg tttccctagc 1740
tgtatttagc ctctgactat attagtatac aaagaggtca tgtggttgag accaggtgaa 1800
tagtcactat cagtgtggag acaagcacag cacacagaca ttttaggaag gaaaggaact 1860
acgaaatcgt gtgaaaatgg gttggaaccc atcagtgatc gcatattcat tgatgagggt 1920
ttgcttgaga tagaaaatgg tggctccttt ctgtcttatc tcctagtttc ttcaatgctt 1980
acgccttgtt cttctcaaga gaaagttgta actctctggt cttcatatgt ccctgtgctc 2040
cttttaacca aataaagagt tcttgtttct gaagaa                           2076

<210> 62
<211> 2418
<212> DNA
<213> Homo sapiens

<400> 62
ctgtggtgtt tttcccccgc tcctctggct gccttcctga tggatctctg tggtcccagg 60
caggaatggc ctgcttgggg acccagcgag ctcccaaggc ctttcctgct gcttcctcta 120
tccctgtgtt ttgcttggct ctctaaattg actcagctcc aggacatcag gaccccaggt 180
tctctggtct tgggactctg agacttgcac caggaatcct gcccaggctc tcaggccttt 240
ggactcagac tgagctactt cactggcttt cctggttctc cagcttgaag atggcagatc 300
gtgggacttc tcagcctcca taattgagtg agccaattcc ctggccaaaa ggtgtgtttt 360
gctgacttca agcatccctg ctacaaaatg gcctacttcc atgaactgtc cagccgagtg 420
agctttcagg aggcacgcct ggcttgtgag agtgagggag gagtcctcct cagccttgag 480
aatgaagcag aacagaagtt aatagagagc atgttgcaaa acctgacaaa acccgggaca 540
gggatttctg atggtgattt ctggataggg ctttggagga atggagatgg gcaaacatct 600
ggtgcctgcc cagatctcta ccagtggtct gatggaagca attcccagta ccgaaactgg 660
tacacagatg aaccttcctg cggaagtgaa aagtgtgttg tgatgtatca ccaaccaact 720
gccaatcctg gccttggggg tccctacctt taccagtgga atgatgacag gtgtaacatg 780
aagcacaatt atatttgcaa gtatgaacca gagattaatc caacagcccc tgtagaaaag 840
ccttatctta caaatcaacc aggagacacc catcagaatg tggttgttac tgaagcaggt 900
ataattccca atctaattta tgttgttata ccaacaatac ccctgctctt actgatactg 960
gttgcttttg gaacctgttg tttccagatg ctgcataaaa gtaaaggaag aacaaaaact 1020
agtccaaacc agtctacact gtggatttca aagagtacca gaaaagaaag tggcatggaa 1080
gtataataac tcattgactt ggttccagaa ttttgtaatt ctggatctgt ataaggaatg 1140
gcatcagaac aatagcttgg aatggcttga aatcacaaag gatctgcaag atgaactgta 1200
agctccccct tgaggcaaat attaaagtaa tttttatatg tctattattt catttaaaga 1260
atatgctgtg ctaataatgg agtgagacat gcttattttg ctaaaggatg cacccaaact 1320
tcaaacttca agcaaatgaa atggacaatg cagataaagt tgttatcaac acgtcgggag 1380
tatgtgtgtt agaagcaatt ccttttattt ctttcacctt tcataagttg ttatctagtc 1440
aatgtaatgt atattgtatt gaaatttaca gtgtgcaaaa gtattttacc tttgcataag 1500
tgtttgataa aaatgaactg ttctaatatt tatttttatg gcatctcatt tttcaataca 1560
tgctcttttg attaaagaaa cttattactg ttgtcaactg aattcacaca cacacaaata 1620
tagtaccata gaaaaagttt gttttctcga aataattcat ctttcagctt ctctgctttt 1680
ggtcaatgtc taggaaatct cttcagaaat aagaagctat ttcattaagt gtgatataaa 1740
cctcctcaaa cattttactt agaggcaagg attgtctaat ttcaattgtg caagacatgt 1800
gccttataat tatttttagc ttaaaattaa acagattttg taataatgta actttgttaa 1860
taggtgcata aacactaatg cagtcaattt gaacaaaaga agtgacatac acaatataaa 1920
tcatatgtct tcacacgttg cctatataat gagaagcagc tctctgaggg ttctgaaatc 1980
aatgtggtcc ctctcttgcc cactaaacaa agatggttgt tcggggtttg ggattgacac 2040
tggaggcaga tagttgcaaa gttagtctaa ggtttcccta gctgtattta gcctctgact 2100
atattagtat acaaagaggt catgtggttg agaccaggtg aatagtcact atcagtgtgg 2160
agacaagcac agcacacaga cattttagga aggaaaggaa ctacgaaatc gtgtgaaaat 2220
gggttggaac ccatcagtga tcgcatattc attgatgagg gtttgcttga gatagaaaat 2280
ggtggctcct ttctgtctta tctcctagtt tcttcaatgc ttacgccttg ttcttctcaa 2340
gagaaagttg taactctctg gtcttcatat gtccctgtgc tccttttaac caaataaaga 2400
gttcttgttt ctgaagaa                                               2418

<210> 63
<211> 232
<212> PRT
<213> Homo sapiens

<400> 63
Met Ala Tyr Phe His Glu Leu Ser Ser Arg Val Ser Phe Gln Glu Ala
 1               5                  10                  15      
Arg Leu Ala Cys Glu Ser Glu Gly Gly Val Leu Leu Ser Leu Glu Asn
            20                  25                  30          
Glu Ala Glu Gln Lys Leu Ile Glu Ser Met Leu Gln Asn Leu Thr Lys
        35                  40                  45              
Pro Gly Thr Gly Ile Ser Asp Gly Asp Phe Trp Ile Gly Leu Trp Arg
    50                  55                  60                  
Asn Gly Asp Gly Gln Thr Ser Gly Ala Cys Pro Asp Leu Tyr Gln Trp
65                  70                  75                  80  
Ser Asp Gly Ser Asn Ser Gln Tyr Arg Asn Trp Tyr Thr Asp Glu Pro
                85                  90                  95      
Ser Cys Gly Ser Glu Lys Cys Val Val Met Tyr His Gln Pro Thr Ala
            100                 105                 110         
Asn Pro Gly Leu Gly Gly Pro Tyr Leu Tyr Gln Trp Asn Asp Asp Arg
        115                 120                 125             
Cys Asn Met Lys His Asn Tyr Ile Cys Lys Tyr Glu Pro Glu Ile Asn
    130                 135                 140                 
Pro Thr Ala Pro Val Glu Lys Pro Tyr Leu Thr Asn Gln Pro Gly Asp
145                 150                 155                 160 
Thr His Gln Asn Val Val Val Thr Glu Ala Gly Ile Ile Pro Asn Leu
                165                 170                 175     
Ile Tyr Val Val Ile Pro Thr Ile Pro Leu Leu Leu Leu Ile Leu Val
            180                 185                 190         
Ala Phe Gly Thr Cys Cys Phe Gln Met Leu His Lys Ser Lys Gly Arg
        195                 200                 205             
Thr Lys Thr Ser Pro Asn Gln Ser Thr Leu Trp Ile Ser Lys Ser Thr
    210                 215                 220                 
Arg Lys Glu Ser Gly Met Glu Val
225                 230         


<210> 64
<211> 232
<212> PRT
<213> Homo sapiens

<400> 64
Met Ala Tyr Phe His Glu Leu Ser Ser Arg Val Ser Phe Gln Glu Ala
 1               5                  10                  15      
Arg Leu Ala Cys Glu Ser Glu Gly Gly Val Leu Leu Ser Leu Glu Asn
            20                  25                  30          
Glu Ala Glu Gln Lys Leu Ile Glu Ser Met Leu Gln Asn Leu Thr Lys
        35                  40                  45              
Pro Gly Thr Gly Ile Ser Asp Gly Asp Phe Trp Ile Gly Leu Trp Arg
    50                  55                  60                  
Asn Gly Asp Gly Gln Thr Ser Gly Ala Cys Pro Asp Leu Tyr Gln Trp
65                  70                  75                  80  
Ser Asp Gly Ser Asn Ser Gln Tyr Arg Asn Trp Tyr Thr Asp Glu Pro
                85                  90                  95      
Ser Cys Gly Ser Glu Lys Cys Val Val Met Tyr His Gln Pro Thr Ala
            100                 105                 110         
Asn Pro Gly Leu Gly Gly Pro Tyr Leu Tyr Gln Trp Asn Asp Asp Arg
        115                 120                 125             
Cys Asn Met Lys His Asn Tyr Ile Cys Lys Tyr Glu Pro Glu Ile Asn
    130                 135                 140                 
Pro Thr Ala Pro Val Glu Lys Pro Tyr Leu Thr Asn Gln Pro Gly Asp
145                 150                 155                 160 
Thr His Gln Asn Val Val Val Thr Glu Ala Gly Ile Ile Pro Asn Leu
                165                 170                 175     
Ile Tyr Val Val Ile Pro Thr Ile Pro Leu Leu Leu Leu Ile Leu Val
            180                 185                 190         
Ala Phe Gly Thr Cys Cys Phe Gln Met Leu His Lys Ser Lys Gly Arg
        195                 200                 205             
Thr Lys Thr Ser Pro Asn Gln Ser Thr Leu Trp Ile Ser Lys Ser Thr
    210                 215                 220                 
Arg Lys Glu Ser Gly Met Glu Val
225                 230         


<210> 65
<211> 232
<212> PRT
<213> Homo sapiens

<400> 65
Met Ala Tyr Phe His Glu Leu Ser Ser Arg Val Ser Phe Gln Glu Ala
 1               5                  10                  15      
Arg Leu Ala Cys Glu Ser Glu Gly Gly Val Leu Leu Ser Leu Glu Asn
            20                  25                  30          
Glu Ala Glu Gln Lys Leu Ile Glu Ser Met Leu Gln Asn Leu Thr Lys
        35                  40                  45              
Pro Gly Thr Gly Ile Ser Asp Gly Asp Phe Trp Ile Gly Leu Trp Arg
    50                  55                  60                  
Asn Gly Asp Gly Gln Thr Ser Gly Ala Cys Pro Asp Leu Tyr Gln Trp
65                  70                  75                  80  
Ser Asp Gly Ser Asn Ser Gln Tyr Arg Asn Trp Tyr Thr Asp Glu Pro
                85                  90                  95      
Ser Cys Gly Ser Glu Lys Cys Val Val Met Tyr His Gln Pro Thr Ala
            100                 105                 110         
Asn Pro Gly Leu Gly Gly Pro Tyr Leu Tyr Gln Trp Asn Asp Asp Arg
        115                 120                 125             
Cys Asn Met Lys His Asn Tyr Ile Cys Lys Tyr Glu Pro Glu Ile Asn
    130                 135                 140                 
Pro Thr Ala Pro Val Glu Lys Pro Tyr Leu Thr Asn Gln Pro Gly Asp
145                 150                 155                 160 
Thr His Gln Asn Val Val Val Thr Glu Ala Gly Ile Ile Pro Asn Leu
                165                 170                 175     
Ile Tyr Val Val Ile Pro Thr Ile Pro Leu Leu Leu Leu Ile Leu Val
            180                 185                 190         
Ala Phe Gly Thr Cys Cys Phe Gln Met Leu His Lys Ser Lys Gly Arg
        195                 200                 205             
Thr Lys Thr Ser Pro Asn Gln Ser Thr Leu Trp Ile Ser Lys Ser Thr
    210                 215                 220                 
Arg Lys Glu Ser Gly Met Glu Val
225                 230         


<210> 66
<211> 2236
<212> DNA
<213> Homo sapiens

<400> 66
gcttgaagat ggcagatcgt gggacttctc agcctccata attgagtgag ccaattccct 60
gaatacaaca agaagatggc catctgtaga ccaggaggtg gtccctcccc agaaactgga 120
tgggccagca cgttgattct gagcttctag cctccagaac tgccaaaagg tgtgttttgc 180
tgacttcaag catccctgct acaaaatggc ctacttccat gaactgtcca gccgagtgag 240
ctttcaggag gcacgcctgg cttgtgagag tgagggagga gtcctcctca gccttgagaa 300
tgaagcagaa cagaagttaa tagagagcat gttgcaaaac ctgacaaaac ccgggacagg 360
gatttctgat ggtgatttct ggatagggct ttggaggaat ggagatgggc aaacatctgg 420
tgcctgccca gatctctacc agtggtctga tggaagcaat tcccagtacc gaaactggta 480
cacagatgaa ccttcctgcg gaagtgaaaa gtgtgttgtg atgtatcacc aaccaactgc 540
caatcctggc cttgggggtc cctaccttta ccagtggaat gatgacaggt gtaacatgaa 600
gcacaattat atttgcaagt atgaaccaga gattaatcca acagcccctg tagaaaagcc 660
ttatcttaca aatcaaccag gagacaccca tcagaatgtg gttgttactg aagcaggtat 720
aattcccaat ctaatttatg ttgttatacc aacaataccc ctgctcttac tgatactggt 780
tgcttttgga acctgttgtt tccagatgct gcataaaagt aaaggaagaa caaaaactag 840
tccaaaccag tctacactgt ggatttcaaa gagtaccaga aaagaaagtg gcatggaagt 900
ataataactc attgacttgg ttccagaatt ttgtaattct ggatctgtat aaggaatggc 960
atcagaacaa tagcttggaa tggcttgaaa tcacaaagga tctgcaagat gaactgtaag 1020
ctcccccttg aggcaaatat taaagtaatt tttatatgtc tattatttca tttaaagaat 1080
atgctgtgct aataatggag tgagacatgc ttattttgct aaaggatgca cccaaacttc 1140
aaacttcaag caaatgaaat ggacaatgca gataaagttg ttatcaacac gtcgggagta 1200
tgtgtgttag aagcaattcc ttttatttct ttcacctttc ataagttgtt atctagtcaa 1260
tgtaatgtat attgtattga aatttacagt gtgcaaaagt attttacctt tgcataagtg 1320
tttgataaaa atgaactgtt ctaatattta tttttatggc atctcatttt tcaatacatg 1380
ctcttttgat taaagaaact tattactgtt gtcaactgaa ttcacacaca cacaaatata 1440
gtaccataga aaaagtttgt tttctcgaaa taattcatct ttcagcttct ctgcttttgg 1500
tcaatgtcta ggaaatctct tcagaaataa gaagctattt cattaagtgt gatataaacc 1560
tcctcaaaca ttttacttag aggcaaggat tgtctaattt caattgtgca agacatgtgc 1620
cttataatta tttttagctt aaaattaaac agattttgta ataatgtaac tttgttaata 1680
ggtgcataaa cactaatgca gtcaatttga acaaaagaag tgacatacac aatataaatc 1740
atatgtcttc acacgttgcc tatataatga gaagcagctc tctgagggtt ctgaaatcaa 1800
tgtggtccct ctcttgccca ctaaacaaag atggttgttc ggggtttggg attgacactg 1860
gaggcagata gttgcaaagt tagtctaagg tttccctagc tgtatttagc ctctgactat 1920
attagtatac aaagaggtca tgtggttgag accaggtgaa tagtcactat cagtgtggag 1980
acaagcacag cacacagaca ttttaggaag gaaaggaact acgaaatcgt gtgaaaatgg 2040
gttggaaccc atcagtgatc gcatattcat tgatgagggt ttgcttgaga tagaaaatgg 2100
tggctccttt ctgtcttatc tcctagtttc ttcaatgctt acgccttgtt cttctcaaga 2160
gaaagttgta actctctggt cttcatatgt ccctgtgctc cttttaacca aataaagagt 2220
tcttgtttct gaagaa                                                 2236

<210> 67
<211> 2076
<212> DNA
<213> Homo sapiens

<400> 67
ggccaaaagg tgtgttttgc tgacttcaag catccctgct acaaaatggc ctacttccat 60
gaactgtcca gccgagtgag ctttcaggag gcacgcctgg cttgtgagag tgagggagga 120
gtcctcctca gccttgagaa tgaagcagaa cagaagttaa tagagagcat gttgcaaaac 180
ctgacaaaac ccgggacagg gatttctgat ggtgatttct ggatagggct ttggaggaat 240
ggagatgggc aaacatctgg tgcctgccca gatctctacc agtggtctga tggaagcaat 300
tcccagtacc gaaactggta cacagatgaa ccttcctgcg gaagtgaaaa gtgtgttgtg 360
atgtatcacc aaccaactgc caatcctggc cttgggggtc cctaccttta ccagtggaat 420
gatgacaggt gtaacatgaa gcacaattat atttgcaagt atgaaccaga gattaatcca 480

acagcccctg tagaaaagcc ttatcttaca aatcaaccag gagacaccca tcagaatgtg 540
gttgttactg aagcaggtat aattcccaat ctaatttatg ttgttatacc aacaataccc 600
ctgctcttac tgatactggt tgcttttgga acctgttgtt tccagatgct gcataaaagt 660
aaaggaagaa caaaaactag tccaaaccag tctacactgt ggatttcaaa gagtaccaga 720
aaagaaagtg gcatggaagt ataataactc attgacttgg ttccagaatt ttgtaattct 780
ggatctgtat aaggaatggc atcagaacaa tagcttggaa tggcttgaaa tcacaaagga 840
tctgcaagat gaactgtaag ctcccccttg aggcaaatat taaagtaatt tttatatgtc 900
tattatttca tttaaagaat atgctgtgct aataatggag tgagacatgc ttattttgct 960
aaaggatgca cccaaacttc aaacttcaag caaatgaaat ggacaatgca gataaagttg 1020
ttatcaacac gtcgggagta tgtgtgttag aagcaattcc ttttatttct ttcacctttc 1080
ataagttgtt atctagtcaa tgtaatgtat attgtattga aatttacagt gtgcaaaagt 1140
attttacctt tgcataagtg tttgataaaa atgaactgtt ctaatattta tttttatggc 1200
atctcatttt tcaatacatg ctcttttgat taaagaaact tattactgtt gtcaactgaa 1260
ttcacacaca cacaaatata gtaccataga aaaagtttgt tttctcgaaa taattcatct 1320
ttcagcttct ctgcttttgg tcaatgtcta ggaaatctct tcagaaataa gaagctattt 1380
cattaagtgt gatataaacc tcctcaaaca ttttacttag aggcaaggat tgtctaattt 1440
caattgtgca agacatgtgc cttataatta tttttagctt aaaattaaac agattttgta 1500
ataatgtaac tttgttaata ggtgcataaa cactaatgca gtcaatttga acaaaagaag 1560
tgacatacac aatataaatc atatgtcttc acacgttgcc tatataatga gaagcagctc 1620
tctgagggtt ctgaaatcaa tgtggtccct ctcttgccca ctaaacaaag atggttgttc 1680
ggggtttggg attgacactg gaggcagata gttgcaaagt tagtctaagg tttccctagc 1740
tgtatttagc ctctgactat attagtatac aaagaggtca tgtggttgag accaggtgaa 1800
tagtcactat cagtgtggag acaagcacag cacacagaca ttttaggaag gaaaggaact 1860
acgaaatcgt gtgaaaatgg gttggaaccc atcagtgatc gcatattcat tgatgagggt 1920
ttgcttgaga tagaaaatgg tggctccttt ctgtcttatc tcctagtttc ttcaatgctt 1980

acgccttgtt cttctcaaga gaaagttgta actctctggt cttcatatgt ccctgtgctc 2040
cttttaacca aataaagagt tcttgtttct gaagaa                           2076

<210> 68
<211> 2236
<212> DNA
<213> Homo sapiens

<400> 68
gcttgaagat ggcagatcgt gggacttctc agcctccata attgagtgag ccaattccct 60
gaatacaaca agaagatggc catctgtaga ccaggaggtg gtccctcccc agaaactgga 120
tgggccagca cgttgattct gagcttctag cctccagaac tgccaaaagg tgtgttttgc 180
tgacttcaag catccctgct acaaaatggc ctacttccat gaactgtcca gccgagtgag 240
ctttcaggag gcacgcctgg cttgtgagag tgagggagga gtcctcctca gccttgagaa 300
tgaagcagaa cagaagttaa tagagagcat gttgcaaaac ctgacaaaac ccgggacagg 360
gatttctgat ggtgatttct ggatagggct ttggaggaat ggagatgggc aaacatctgg 420
tgcctgccca gatctctacc agtggtctga tggaagcaat tcccagtacc gaaactggta 480
cacagatgaa ccttcctgcg gaagtgaaaa gtgtgttgtg atgtatcacc aaccaactgc 540
caatcctggc cttgggggtc cctaccttta ccagtggaat gatgacaggt gtaacatgaa 600
gcacaattat atttgcaagt atgaaccaga gattaatcca acagcccctg tagaaaagcc 660
ttatcttaca aatcaaccag gagacaccca tcagaatgtg gttgttactg aagcaggtat 720
aattcccaat ctaatttatg ttgttatacc aacaataccc ctgctcttac tgatactggt 780
tgcttttgga acctgttgtt tccagatgct gcataaaagt aaaggaagaa caaaaactag 840
tccaaaccag tctacactgt ggatttcaaa gagtaccaga aaagaaagtg gcatggaagt 900
ataataactc attgacttgg ttccagaatt ttgtaattct ggatctgtat aaggaatggc 960
atcagaacaa tagcttggaa tggcttgaaa tcacaaagga tctgcaagat gaactgtaag 1020
ctcccccttg aggcaaatat taaagtaatt tttatatgtc tattatttca tttaaagaat 1080
atgctgtgct aataatggag tgagacatgc ttattttgct aaaggatgca cccaaacttc 1140
aaacttcaag caaatgaaat ggacaatgca gataaagttg ttatcaacac gtcgggagta 1200
tgtgtgttag aagcaattcc ttttatttct ttcacctttc ataagttgtt atctagtcaa 1260
tgtaatgtat attgtattga aatttacagt gtgcaaaagt attttacctt tgcataagtg 1320
tttgataaaa atgaactgtt ctaatattta tttttatggc atctcatttt tcaatacatg 1380
ctcttttgat taaagaaact tattactgtt gtcaactgaa ttcacacaca cacaaatata 1440
gtaccataga aaaagtttgt tttctcgaaa taattcatct ttcagcttct ctgcttttgg 1500
tcaatgtcta ggaaatctct tcagaaataa gaagctattt cattaagtgt gatataaacc 1560
tcctcaaaca ttttacttag aggcaaggat tgtctaattt caattgtgca agacatgtgc 1620
cttataatta tttttagctt aaaattaaac agattttgta ataatgtaac tttgttaata 1680
ggtgcataaa cactaatgca gtcaatttga acaaaagaag tgacatacac aatataaatc 1740
atatgtcttc acacgttgcc tatataatga gaagcagctc tctgagggtt ctgaaatcaa 1800
tgtggtccct ctcttgccca ctaaacaaag atggttgttc ggggtttggg attgacactg 1860
gaggcagata gttgcaaagt tagtctaagg tttccctagc tgtatttagc ctctgactat 1920
attagtatac aaagaggtca tgtggttgag accaggtgaa tagtcactat cagtgtggag 1980
acaagcacag cacacagaca ttttaggaag gaaaggaact acgaaatcgt gtgaaaatgg 2040
gttggaaccc atcagtgatc gcatattcat tgatgagggt ttgcttgaga tagaaaatgg 2100
tggctccttt ctgtcttatc tcctagtttc ttcaatgctt acgccttgtt cttctcaaga 2160
gaaagttgta actctctggt cttcatatgt ccctgtgctc cttttaacca aataaagagt 2220
tcttgtttct gaagaa                                                 2236

<210> 69
<211> 232
<212> PRT
<213> Homo sapiens

<400> 69
Met Ala Tyr Phe His Glu Leu Ser Ser Arg Val Ser Phe Gln Glu Ala
 1               5                  10                  15      
Arg Leu Ala Cys Glu Ser Glu Gly Gly Val Leu Leu Ser Leu Glu Asn
            20                  25                  30          
Glu Ala Glu Gln Lys Leu Ile Glu Ser Met Leu Gln Asn Leu Thr Lys
        35                  40                  45              
Pro Gly Thr Gly Ile Ser Asp Gly Asp Phe Trp Ile Gly Leu Trp Arg
    50                  55                  60                  
Asn Gly Asp Gly Gln Thr Ser Gly Ala Cys Pro Asp Leu Tyr Gln Trp
65                  70                  75                  80  
Ser Asp Gly Ser Asn Ser Gln Tyr Arg Asn Trp Tyr Thr Asp Glu Pro
                85                  90                  95      
Ser Cys Gly Ser Glu Lys Cys Val Val Met Tyr His Gln Pro Thr Ala
            100                 105                 110         
Asn Pro Gly Leu Gly Gly Pro Tyr Leu Tyr Gln Trp Asn Asp Asp Arg
        115                 120                 125             
Cys Asn Met Lys His Asn Tyr Ile Cys Lys Tyr Glu Pro Glu Ile Asn
    130                 135                 140                 
Pro Thr Ala Pro Val Glu Lys Pro Tyr Leu Thr Asn Gln Pro Gly Asp
145                 150                 155                 160 
Thr His Gln Asn Val Val Val Thr Glu Ala Gly Ile Ile Pro Asn Leu
                165                 170                 175     
Ile Tyr Val Val Ile Pro Thr Ile Pro Leu Leu Leu Leu Ile Leu Val
            180                 185                 190         
Ala Phe Gly Thr Cys Cys Phe Gln Met Leu His Lys Ser Lys Gly Arg
        195                 200                 205             
Thr Lys Thr Ser Pro Asn Gln Ser Thr Leu Trp Ile Ser Lys Ser Thr
    210                 215                 220                 
Arg Lys Glu Ser Gly Met Glu Val
225                 230         


<210> 70
<211> 232
<212> PRT
<213> Homo sapiens

<400> 70
Met Ala Tyr Phe His Glu Leu Ser Ser Arg Val Ser Phe Gln Glu Ala
 1               5                  10                  15      
Arg Leu Ala Cys Glu Ser Glu Gly Gly Val Leu Leu Ser Leu Glu Asn
            20                  25                  30          
Glu Ala Glu Gln Lys Leu Ile Glu Ser Met Leu Gln Asn Leu Thr Lys
        35                  40                  45              
Pro Gly Thr Gly Ile Ser Asp Gly Asp Phe Trp Ile Gly Leu Trp Arg
    50                  55                  60                  
Asn Gly Asp Gly Gln Thr Ser Gly Ala Cys Pro Asp Leu Tyr Gln Trp
65                  70                  75                  80  
Ser Asp Gly Ser Asn Ser Gln Tyr Arg Asn Trp Tyr Thr Asp Glu Pro
                85                  90                  95      
Ser Cys Gly Ser Glu Lys Cys Val Val Met Tyr His Gln Pro Thr Ala
            100                 105                 110         
Asn Pro Gly Leu Gly Gly Pro Tyr Leu Tyr Gln Trp Asn Asp Asp Arg
        115                 120                 125             
Cys Asn Met Lys His Asn Tyr Ile Cys Lys Tyr Glu Pro Glu Ile Asn
    130                 135                 140                 

Pro Thr Ala Pro Val Glu Lys Pro Tyr Leu Thr Asn Gln Pro Gly Asp
145                 150                 155                 160 
Thr His Gln Asn Val Val Val Thr Glu Ala Gly Ile Ile Pro Asn Leu
                165                 170                 175     
Ile Tyr Val Val Ile Pro Thr Ile Pro Leu Leu Leu Leu Ile Leu Val
            180                 185                 190         
Ala Phe Gly Thr Cys Cys Phe Gln Met Leu His Lys Ser Lys Gly Arg
        195                 200                 205             
Thr Lys Thr Ser Pro Asn Gln Ser Thr Leu Trp Ile Ser Lys Ser Thr
    210                 215                 220                 
Arg Lys Glu Ser Gly Met Glu Val
225                 230         


<210> 71
<211> 232
<212> PRT
<213> Homo sapiens

<400> 71
Met Ala Tyr Phe His Glu Leu Ser Ser Arg Val Ser Phe Gln Glu Ala
 1               5                  10                  15      
Arg Leu Ala Cys Glu Ser Glu Gly Gly Val Leu Leu Ser Leu Glu Asn
            20                  25                  30          
Glu Ala Glu Gln Lys Leu Ile Glu Ser Met Leu Gln Asn Leu Thr Lys
        35                  40                  45              
Pro Gly Thr Gly Ile Ser Asp Gly Asp Phe Trp Ile Gly Leu Trp Arg
    50                  55                  60                  
Asn Gly Asp Gly Gln Thr Ser Gly Ala Cys Pro Asp Leu Tyr Gln Trp
65                  70                  75                  80  
Ser Asp Gly Ser Asn Ser Gln Tyr Arg Asn Trp Tyr Thr Asp Glu Pro
                85                  90                  95      
Ser Cys Gly Ser Glu Lys Cys Val Val Met Tyr His Gln Pro Thr Ala
            100                 105                 110         
Asn Pro Gly Leu Gly Gly Pro Tyr Leu Tyr Gln Trp Asn Asp Asp Arg
        115                 120                 125             
Cys Asn Met Lys His Asn Tyr Ile Cys Lys Tyr Glu Pro Glu Ile Asn
    130                 135                 140                 
Pro Thr Ala Pro Val Glu Lys Pro Tyr Leu Thr Asn Gln Pro Gly Asp
145                 150                 155                 160 
Thr His Gln Asn Val Val Val Thr Glu Ala Gly Ile Ile Pro Asn Leu
                165                 170                 175     
Ile Tyr Val Val Ile Pro Thr Ile Pro Leu Leu Leu Leu Ile Leu Val
            180                 185                 190         
Ala Phe Gly Thr Cys Cys Phe Gln Met Leu His Lys Ser Lys Gly Arg
        195                 200                 205             
Thr Lys Thr Ser Pro Asn Gln Ser Thr Leu Trp Ile Ser Lys Ser Thr
    210                 215                 220                 
Arg Lys Glu Ser Gly Met Glu Val
225                 230         


<210> 72
<211> 2133
<212> DNA
<213> Homo sapiens

<400> 72
gcttgaagat ggcagatcgt gggacttctc agcctccata attgagtgag ccaattccct 60
gaatacaaca agaagatggc catctgtaga ccaggaggtg gtccctcccc agaaactgga 120
tgggccagca cgttgattct gagcttctag cctccagaac tgccaaaagg tgtgttttgc 180
tgacttcaag catccctgct acaaaatggc ctacttccat gaactgtcca gccgagtgag 240
ctttcaggag gcacgcctgg cttgtgagag tgagggagga gtcctcctca gccttgagaa 300
tgaagcagaa cagaagttaa tagagagcat gttgcaaaac ctgacaaaac ccgggacagg 360
gatttctgat ggtgatttct ggatagggct ttggaggaat ggagatgggc aaacatctgg 420
tgcctgccca gatctctacc agtggtctga tggaagcaat tcccagtacc gaaactggta 480
cacagatgaa ccttcctgcg gaagtgaaaa gtgtgttgtg atgtatcacc aaccaactgc 540
caatcctggc cttgggggtc cctaccttta ccagtggaat gatgacaggt gtaacatgaa 600
gcacaattat atttgcaagt atgaaccaga gattaatcca acagcccctg tagaaaagcc 660
ttatcttaca aatcaaccag gagacaccca tcagaatgtg gttgttactg aagcagtaaa 720
ggaagaacaa aaactagtcc aaaccagtct acactgtgga tttcaaagag taccagaaaa 780
gaaagtggca tggaagtata ataactcatt gacttggttc cagaattttg taattctgga 840
tctgtataag gaatggcatc agaacaatag cttggaatgg cttgaaatca caaaggatct 900
gcaagatgaa ctgtaagctc ccccttgagg caaatattaa agtaattttt atatgtctat 960
tatttcattt aaagaatatg ctgtgctaat aatggagtga gacatgctta ttttgctaaa 1020
ggatgcaccc aaacttcaaa cttcaagcaa atgaaatgga caatgcagat aaagttgtta 1080
tcaacacgtc gggagtatgt gtgttagaag caattccttt tatttctttc acctttcata 1140
agttgttatc tagtcaatgt aatgtatatt gtattgaaat ttacagtgtg caaaagtatt 1200
ttacctttgc ataagtgttt gataaaaatg aactgttcta atatttattt ttatggcatc 1260
tcatttttca atacatgctc ttttgattaa agaaacttat tactgttgtc aactgaattc 1320
acacacacac aaatatagta ccatagaaaa agtttgtttt ctcgaaataa ttcatctttc 1380
agcttctctg cttttggtca atgtctagga aatctcttca gaaataagaa gctatttcat 1440
taagtgtgat ataaacctcc tcaaacattt tacttagagg caaggattgt ctaatttcaa 1500
ttgtgcaaga catgtgcctt ataattattt ttagcttaaa attaaacaga ttttgtaata 1560
atgtaacttt gttaataggt gcataaacac taatgcagtc aatttgaaca aaagaagtga 1620
catacacaat ataaatcata tgtcttcaca cgttgcctat ataatgagaa gcagctctct 1680
gagggttctg aaatcaatgt ggtccctctc ttgcccacta aacaaagatg gttgttcggg 1740
gtttgggatt gacactggag gcagatagtt gcaaagttag tctaaggttt ccctagctgt 1800
atttagcctc tgactatatt agtatacaaa gaggtcatgt ggttgagacc aggtgaatag 1860
tcactatcag tgtggagaca agcacagcac acagacattt taggaaggaa aggaactacg 1920
aaatcgtgtg aaaatgggtt ggaacccatc agtgatcgca tattcattga tgagggtttg 1980
cttgagatag aaaatggtgg ctcctttctg tcttatctcc tagtttcttc aatgcttacg 2040
ccttgttctt ctcaagagaa agttgtaact ctctggtctt catatgtccc tgtgctcctt 2100
ttaaccaaat aaagagttct tgtttctgaa gaa                              2133

<210> 73
<211> 2076
<212> DNA
<213> Homo sapiens

<400> 73
ggccaaaagg tgtgttttgc tgacttcaag catccctgct acaaaatggc ctacttccat 60
gaactgtcca gccgagtgag ctttcaggag gcacgcctgg cttgtgagag tgagggagga 120
gtcctcctca gccttgagaa tgaagcagaa cagaagttaa tagagagcat gttgcaaaac 180
ctgacaaaac ccgggacagg gatttctgat ggtgatttct ggatagggct ttggaggaat 240
ggagatgggc aaacatctgg tgcctgccca gatctctacc agtggtctga tggaagcaat 300
tcccagtacc gaaactggta cacagatgaa ccttcctgcg gaagtgaaaa gtgtgttgtg 360
atgtatcacc aaccaactgc caatcctggc cttgggggtc cctaccttta ccagtggaat 420
gatgacaggt gtaacatgaa gcacaattat atttgcaagt atgaaccaga gattaatcca 480
acagcccctg tagaaaagcc ttatcttaca aatcaaccag gagacaccca tcagaatgtg 540
gttgttactg aagcaggtat aattcccaat ctaatttatg ttgttatacc aacaataccc 600
ctgctcttac tgatactggt tgcttttgga acctgttgtt tccagatgct gcataaaagt 660
aaaggaagaa caaaaactag tccaaaccag tctacactgt ggatttcaaa gagtaccaga 720
aaagaaagtg gcatggaagt ataataactc attgacttgg ttccagaatt ttgtaattct 780
ggatctgtat aaggaatggc atcagaacaa tagcttggaa tggcttgaaa tcacaaagga 840
tctgcaagat gaactgtaag ctcccccttg aggcaaatat taaagtaatt tttatatgtc 900
tattatttca tttaaagaat atgctgtgct aataatggag tgagacatgc ttattttgct 960
aaaggatgca cccaaacttc aaacttcaag caaatgaaat ggacaatgca gataaagttg 1020
ttatcaacac gtcgggagta tgtgtgttag aagcaattcc ttttatttct ttcacctttc 1080
ataagttgtt atctagtcaa tgtaatgtat attgtattga aatttacagt gtgcaaaagt 1140
attttacctt tgcataagtg tttgataaaa atgaactgtt ctaatattta tttttatggc 1200
atctcatttt tcaatacatg ctcttttgat taaagaaact tattactgtt gtcaactgaa 1260
ttcacacaca cacaaatata gtaccataga aaaagtttgt tttctcgaaa taattcatct 1320
ttcagcttct ctgcttttgg tcaatgtcta ggaaatctct tcagaaataa gaagctattt 1380
cattaagtgt gatataaacc tcctcaaaca ttttacttag aggcaaggat tgtctaattt 1440
caattgtgca agacatgtgc cttataatta tttttagctt aaaattaaac agattttgta 1500
ataatgtaac tttgttaata ggtgcataaa cactaatgca gtcaatttga acaaaagaag 1560
tgacatacac aatataaatc atatgtcttc acacgttgcc tatataatga gaagcagctc 1620
tctgagggtt ctgaaatcaa tgtggtccct ctcttgccca ctaaacaaag atggttgttc 1680
ggggtttggg attgacactg gaggcagata gttgcaaagt tagtctaagg tttccctagc 1740
tgtatttagc ctctgactat attagtatac aaagaggtca tgtggttgag accaggtgaa 1800
tagtcactat cagtgtggag acaagcacag cacacagaca ttttaggaag gaaaggaact 1860
acgaaatcgt gtgaaaatgg gttggaaccc atcagtgatc gcatattcat tgatgagggt 1920
ttgcttgaga tagaaaatgg tggctccttt ctgtcttatc tcctagtttc ttcaatgctt 1980
acgccttgtt cttctcaaga gaaagttgta actctctggt cttcatatgt ccctgtgctc 2040
cttttaacca aataaagagt tcttgtttct gaagaa                           2076

<210> 74
<211> 2133
<212> DNA
<213> Homo sapiens

<400> 74
gcttgaagat ggcagatcgt gggacttctc agcctccata attgagtgag ccaattccct 60
gaatacaaca agaagatggc catctgtaga ccaggaggtg gtccctcccc agaaactgga 120
tgggccagca cgttgattct gagcttctag cctccagaac tgccaaaagg tgtgttttgc 180
tgacttcaag catccctgct acaaaatggc ctacttccat gaactgtcca gccgagtgag 240
ctttcaggag gcacgcctgg cttgtgagag tgagggagga gtcctcctca gccttgagaa 300
tgaagcagaa cagaagttaa tagagagcat gttgcaaaac ctgacaaaac ccgggacagg 360
gatttctgat ggtgatttct ggatagggct ttggaggaat ggagatgggc aaacatctgg 420
tgcctgccca gatctctacc agtggtctga tggaagcaat tcccagtacc gaaactggta 480
cacagatgaa ccttcctgcg gaagtgaaaa gtgtgttgtg atgtatcacc aaccaactgc 540
caatcctggc cttgggggtc cctaccttta ccagtggaat gatgacaggt gtaacatgaa 600
gcacaattat atttgcaagt atgaaccaga gattaatcca acagcccctg tagaaaagcc 660
ttatcttaca aatcaaccag gagacaccca tcagaatgtg gttgttactg aagcagtaaa 720
ggaagaacaa aaactagtcc aaaccagtct acactgtgga tttcaaagag taccagaaaa 780
gaaagtggca tggaagtata ataactcatt gacttggttc cagaattttg taattctgga 840
tctgtataag gaatggcatc agaacaatag cttggaatgg cttgaaatca caaaggatct 900
gcaagatgaa ctgtaagctc ccccttgagg caaatattaa agtaattttt atatgtctat 960
tatttcattt aaagaatatg ctgtgctaat aatggagtga gacatgctta ttttgctaaa 1020
ggatgcaccc aaacttcaaa cttcaagcaa atgaaatgga caatgcagat aaagttgtta 1080
tcaacacgtc gggagtatgt gtgttagaag caattccttt tatttctttc acctttcata 1140
agttgttatc tagtcaatgt aatgtatatt gtattgaaat ttacagtgtg caaaagtatt 1200
ttacctttgc ataagtgttt gataaaaatg aactgttcta atatttattt ttatggcatc 1260
tcatttttca atacatgctc ttttgattaa agaaacttat tactgttgtc aactgaattc 1320
acacacacac aaatatagta ccatagaaaa agtttgtttt ctcgaaataa ttcatctttc 1380
agcttctctg cttttggtca atgtctagga aatctcttca gaaataagaa gctatttcat 1440
taagtgtgat ataaacctcc tcaaacattt tacttagagg caaggattgt ctaatttcaa 1500
ttgtgcaaga catgtgcctt ataattattt ttagcttaaa attaaacaga ttttgtaata 1560
atgtaacttt gttaataggt gcataaacac taatgcagtc aatttgaaca aaagaagtga 1620
catacacaat ataaatcata tgtcttcaca cgttgcctat ataatgagaa gcagctctct 1680
gagggttctg aaatcaatgt ggtccctctc ttgcccacta aacaaagatg gttgttcggg 1740
gtttgggatt gacactggag gcagatagtt gcaaagttag tctaaggttt ccctagctgt 1800
atttagcctc tgactatatt agtatacaaa gaggtcatgt ggttgagacc aggtgaatag 1860
tcactatcag tgtggagaca agcacagcac acagacattt taggaaggaa aggaactacg 1920
aaatcgtgtg aaaatgggtt ggaacccatc agtgatcgca tattcattga tgagggtttg 1980
cttgagatag aaaatggtgg ctcctttctg tcttatctcc tagtttcttc aatgcttacg 2040
ccttgttctt ctcaagagaa agttgtaact ctctggtctt catatgtccc tgtgctcctt 2100
ttaaccaaat aaagagttct tgtttctgaa gaa                              2133

<210> 75
<211> 236
<212> PRT
<213> Homo sapiens

<400> 75
Met Ala Tyr Phe His Glu Leu Ser Ser Arg Val Ser Phe Gln Glu Ala
 1               5                  10                  15      
Arg Leu Ala Cys Glu Ser Glu Gly Gly Val Leu Leu Ser Leu Glu Asn
            20                  25                  30          
Glu Ala Glu Gln Lys Leu Ile Glu Ser Met Leu Gln Asn Leu Thr Lys
        35                  40                  45              
Pro Gly Thr Gly Ile Ser Asp Gly Asp Phe Trp Ile Gly Leu Trp Arg
    50                  55                  60                  
Asn Gly Asp Gly Gln Thr Ser Gly Ala Cys Pro Asp Leu Tyr Gln Trp
65                  70                  75                  80  
Ser Asp Gly Ser Asn Ser Gln Tyr Arg Asn Trp Tyr Thr Asp Glu Pro
                85                  90                  95      
Ser Cys Gly Ser Glu Lys Cys Val Val Met Tyr His Gln Pro Thr Ala
            100                 105                 110         
Asn Pro Gly Leu Gly Gly Pro Tyr Leu Tyr Gln Trp Asn Asp Asp Arg
        115                 120                 125             
Cys Asn Met Lys His Asn Tyr Ile Cys Lys Tyr Glu Pro Glu Ile Asn
    130                 135                 140                 
Pro Thr Ala Pro Val Glu Lys Pro Tyr Leu Thr Asn Gln Pro Gly Asp
145                 150                 155                 160 
Thr His Gln Asn Val Val Val Thr Glu Ala Val Lys Glu Glu Gln Lys
                165                 170                 175     
Leu Val Gln Thr Ser Leu His Cys Gly Phe Gln Arg Val Pro Glu Lys
            180                 185                 190         
Lys Val Ala Trp Lys Tyr Asn Asn Ser Leu Thr Trp Phe Gln Asn Phe
        195                 200                 205             
Val Ile Leu Asp Leu Tyr Lys Glu Trp His Gln Asn Asn Ser Leu Glu
    210                 215                 220                 
Trp Leu Glu Ile Thr Lys Asp Leu Gln Asp Glu Leu
225                 230                 235     


<210> 76
<211> 232
<212> PRT
<213> Homo sapiens

<400> 76
Met Ala Tyr Phe His Glu Leu Ser Ser Arg Val Ser Phe Gln Glu Ala
 1               5                  10                  15      
Arg Leu Ala Cys Glu Ser Glu Gly Gly Val Leu Leu Ser Leu Glu Asn
            20                  25                  30          
Glu Ala Glu Gln Lys Leu Ile Glu Ser Met Leu Gln Asn Leu Thr Lys
        35                  40                  45              
Pro Gly Thr Gly Ile Ser Asp Gly Asp Phe Trp Ile Gly Leu Trp Arg
    50                  55                  60                  
Asn Gly Asp Gly Gln Thr Ser Gly Ala Cys Pro Asp Leu Tyr Gln Trp
65                  70                  75                  80  
Ser Asp Gly Ser Asn Ser Gln Tyr Arg Asn Trp Tyr Thr Asp Glu Pro
                85                  90                  95      
Ser Cys Gly Ser Glu Lys Cys Val Val Met Tyr His Gln Pro Thr Ala
            100                 105                 110         
Asn Pro Gly Leu Gly Gly Pro Tyr Leu Tyr Gln Trp Asn Asp Asp Arg
        115                 120                 125             
Cys Asn Met Lys His Asn Tyr Ile Cys Lys Tyr Glu Pro Glu Ile Asn
    130                 135                 140                 
Pro Thr Ala Pro Val Glu Lys Pro Tyr Leu Thr Asn Gln Pro Gly Asp
145                 150                 155                 160 
Thr His Gln Asn Val Val Val Thr Glu Ala Gly Ile Ile Pro Asn Leu
                165                 170                 175     
Ile Tyr Val Val Ile Pro Thr Ile Pro Leu Leu Leu Leu Ile Leu Val
            180                 185                 190         
Ala Phe Gly Thr Cys Cys Phe Gln Met Leu His Lys Ser Lys Gly Arg
        195                 200                 205             
Thr Lys Thr Ser Pro Asn Gln Ser Thr Leu Trp Ile Ser Lys Ser Thr
    210                 215                 220                 
Arg Lys Glu Ser Gly Met Glu Val
225                 230         


<210> 77
<211> 236
<212> PRT
<213> Homo sapiens

<400> 77
Met Ala Tyr Phe His Glu Leu Ser Ser Arg Val Ser Phe Gln Glu Ala
 1               5                  10                  15      
Arg Leu Ala Cys Glu Ser Glu Gly Gly Val Leu Leu Ser Leu Glu Asn
            20                  25                  30          
Glu Ala Glu Gln Lys Leu Ile Glu Ser Met Leu Gln Asn Leu Thr Lys
        35                  40                  45              
Pro Gly Thr Gly Ile Ser Asp Gly Asp Phe Trp Ile Gly Leu Trp Arg
    50                  55                  60                  
Asn Gly Asp Gly Gln Thr Ser Gly Ala Cys Pro Asp Leu Tyr Gln Trp
65                  70                  75                  80  
Ser Asp Gly Ser Asn Ser Gln Tyr Arg Asn Trp Tyr Thr Asp Glu Pro
                85                  90                  95      
Ser Cys Gly Ser Glu Lys Cys Val Val Met Tyr His Gln Pro Thr Ala
            100                 105                 110         
Asn Pro Gly Leu Gly Gly Pro Tyr Leu Tyr Gln Trp Asn Asp Asp Arg
        115                 120                 125             
Cys Asn Met Lys His Asn Tyr Ile Cys Lys Tyr Glu Pro Glu Ile Asn
    130                 135                 140                 
Pro Thr Ala Pro Val Glu Lys Pro Tyr Leu Thr Asn Gln Pro Gly Asp
145                 150                 155                 160 
Thr His Gln Asn Val Val Val Thr Glu Ala Val Lys Glu Glu Gln Lys
                165                 170                 175     
Leu Val Gln Thr Ser Leu His Cys Gly Phe Gln Arg Val Pro Glu Lys
            180                 185                 190         
Lys Val Ala Trp Lys Tyr Asn Asn Ser Leu Thr Trp Phe Gln Asn Phe
        195                 200                 205             
Val Ile Leu Asp Leu Tyr Lys Glu Trp His Gln Asn Asn Ser Leu Glu
    210                 215                 220                 
Trp Leu Glu Ile Thr Lys Asp Leu Gln Asp Glu Leu
225                 230                 235     


<210> 78
<211> 2033
<212> DNA
<213> Homo sapiens

<400> 78
gcttgaagat ggcagatcgt gggacttctc agcctccata attgagtgag ccaattccct 60
ggccaaaagg tgtgttttgc tgacttcaag catccctgct acaaaatggc ctacttccat 120
gaactgtcca gccgagtgag ctttcaggag gcacgcctgg cttgtgagag tgagggagga 180
gtcctcctca gccttgagaa tgaagcagaa cagaagttaa tagagagcat gttgcaaaac 240
ctgacaaaac ccgggacagg gatttctgat ggtgatttct ggatagggct ttggaggaat 300
ggagatgggc aaacatctgg tgcctgccca gatctctacc agtggtctga tggaagcaat 360
tcccagtacc gaaactggta cacagatgaa ccttcctgcg gaagtgaaaa gtgtgttgtg 420
atgtatcacc aaccaactgc caatcctggc cttgggggtc cctaccttta ccagtggaat 480

gatgacaggt gtaacatgaa gcacaattat atttgcaagt atgaaccaga gattaatcca 540
acagcccctg tagaaaagcc ttatcttaca aatcaaccag gagacaccca tcagaatgtg 600
gttgttactg aagcagtaaa ggaagaacaa aaactagtcc aaaccagtct acactgtgga 660
tttcaaagag taccagaaaa gaaagtggca tggaagtata ataactcatt gacttggttc 720
cagaattttg taattctgga tctgtataag gaatggcatc agaacaatag cttggaatgg 780
cttgaaatca caaaggatct gcaagatgaa ctgtaagctc ccccttgagg caaatattaa 840
agtaattttt atatgtctat tatttcattt aaagaatatg ctgtgctaat aatggagtga 900
gacatgctta ttttgctaaa ggatgcaccc aaacttcaaa cttcaagcaa atgaaatgga 960
caatgcagat aaagttgtta tcaacacgtc gggagtatgt gtgttagaag caattccttt 1020
tatttctttc acctttcata agttgttatc tagtcaatgt aatgtatatt gtattgaaat 1080
ttacagtgtg caaaagtatt ttacctttgc ataagtgttt gataaaaatg aactgttcta 1140
atatttattt ttatggcatc tcatttttca atacatgctc ttttgattaa agaaacttat 1200
tactgttgtc aactgaattc acacacacac aaatatagta ccatagaaaa agtttgtttt 1260
ctcgaaataa ttcatctttc agcttctctg cttttggtca atgtctagga aatctcttca 1320
gaaataagaa gctatttcat taagtgtgat ataaacctcc tcaaacattt tacttagagg 1380
caaggattgt ctaatttcaa ttgtgcaaga catgtgcctt ataattattt ttagcttaaa 1440
attaaacaga ttttgtaata atgtaacttt gttaataggt gcataaacac taatgcagtc 1500
aatttgaaca aaagaagtga catacacaat ataaatcata tgtcttcaca cgttgcctat 1560
ataatgagaa gcagctctct gagggttctg aaatcaatgt ggtccctctc ttgcccacta 1620
aacaaagatg gttgttcggg gtttgggatt gacactggag gcagatagtt gcaaagttag 1680
tctaaggttt ccctagctgt atttagcctc tgactatatt agtatacaaa gaggtcatgt 1740
ggttgagacc aggtgaatag tcactatcag tgtggagaca agcacagcac acagacattt 1800
taggaaggaa aggaactacg aaatcgtgtg aaaatgggtt ggaacccatc agtgatcgca 1860
tattcattga tgagggtttg cttgagatag aaaatggtgg ctcctttctg tcttatctcc 1920
tagtttcttc aatgcttacg ccttgttctt ctcaagagaa agttgtaact ctctggtctt 1980

catatgtccc tgtgctcctt ttaaccaaat aaagagttct tgtttctgaa gaa        2033

<210> 79
<211> 2076
<212> DNA
<213> Homo sapiens

<400> 79
ggccaaaagg tgtgttttgc tgacttcaag catccctgct acaaaatggc ctacttccat 60
gaactgtcca gccgagtgag ctttcaggag gcacgcctgg cttgtgagag tgagggagga 120
gtcctcctca gccttgagaa tgaagcagaa cagaagttaa tagagagcat gttgcaaaac 180
ctgacaaaac ccgggacagg gatttctgat ggtgatttct ggatagggct ttggaggaat 240
ggagatgggc aaacatctgg tgcctgccca gatctctacc agtggtctga tggaagcaat 300
tcccagtacc gaaactggta cacagatgaa ccttcctgcg gaagtgaaaa gtgtgttgtg 360
atgtatcacc aaccaactgc caatcctggc cttgggggtc cctaccttta ccagtggaat 420
gatgacaggt gtaacatgaa gcacaattat atttgcaagt atgaaccaga gattaatcca 480
acagcccctg tagaaaagcc ttatcttaca aatcaaccag gagacaccca tcagaatgtg 540
gttgttactg aagcaggtat aattcccaat ctaatttatg ttgttatacc aacaataccc 600
ctgctcttac tgatactggt tgcttttgga acctgttgtt tccagatgct gcataaaagt 660
aaaggaagaa caaaaactag tccaaaccag tctacactgt ggatttcaaa gagtaccaga 720
aaagaaagtg gcatggaagt ataataactc attgacttgg ttccagaatt ttgtaattct 780
ggatctgtat aaggaatggc atcagaacaa tagcttggaa tggcttgaaa tcacaaagga 840
tctgcaagat gaactgtaag ctcccccttg aggcaaatat taaagtaatt tttatatgtc 900
tattatttca tttaaagaat atgctgtgct aataatggag tgagacatgc ttattttgct 960
aaaggatgca cccaaacttc aaacttcaag caaatgaaat ggacaatgca gataaagttg 1020
ttatcaacac gtcgggagta tgtgtgttag aagcaattcc ttttatttct ttcacctttc 1080
ataagttgtt atctagtcaa tgtaatgtat attgtattga aatttacagt gtgcaaaagt 1140
attttacctt tgcataagtg tttgataaaa atgaactgtt ctaatattta tttttatggc 1200
atctcatttt tcaatacatg ctcttttgat taaagaaact tattactgtt gtcaactgaa 1260
ttcacacaca cacaaatata gtaccataga aaaagtttgt tttctcgaaa taattcatct 1320
ttcagcttct ctgcttttgg tcaatgtcta ggaaatctct tcagaaataa gaagctattt 1380
cattaagtgt gatataaacc tcctcaaaca ttttacttag aggcaaggat tgtctaattt 1440
caattgtgca agacatgtgc cttataatta tttttagctt aaaattaaac agattttgta 1500
ataatgtaac tttgttaata ggtgcataaa cactaatgca gtcaatttga acaaaagaag 1560
tgacatacac aatataaatc atatgtcttc acacgttgcc tatataatga gaagcagctc 1620
tctgagggtt ctgaaatcaa tgtggtccct ctcttgccca ctaaacaaag atggttgttc 1680
ggggtttggg attgacactg gaggcagata gttgcaaagt tagtctaagg tttccctagc 1740
tgtatttagc ctctgactat attagtatac aaagaggtca tgtggttgag accaggtgaa 1800
tagtcactat cagtgtggag acaagcacag cacacagaca ttttaggaag gaaaggaact 1860
acgaaatcgt gtgaaaatgg gttggaaccc atcagtgatc gcatattcat tgatgagggt 1920
ttgcttgaga tagaaaatgg tggctccttt ctgtcttatc tcctagtttc ttcaatgctt 1980
acgccttgtt cttctcaaga gaaagttgta actctctggt cttcatatgt ccctgtgctc 2040
cttttaacca aataaagagt tcttgtttct gaagaa                           2076

<210> 80
<211> 2033
<212> DNA
<213> Homo sapiens

<400> 80
gcttgaagat ggcagatcgt gggacttctc agcctccata attgagtgag ccaattccct 60
ggccaaaagg tgtgttttgc tgacttcaag catccctgct acaaaatggc ctacttccat 120
gaactgtcca gccgagtgag ctttcaggag gcacgcctgg cttgtgagag tgagggagga 180
gtcctcctca gccttgagaa tgaagcagaa cagaagttaa tagagagcat gttgcaaaac 240
ctgacaaaac ccgggacagg gatttctgat ggtgatttct ggatagggct ttggaggaat 300
ggagatgggc aaacatctgg tgcctgccca gatctctacc agtggtctga tggaagcaat 360
tcccagtacc gaaactggta cacagatgaa ccttcctgcg gaagtgaaaa gtgtgttgtg 420
atgtatcacc aaccaactgc caatcctggc cttgggggtc cctaccttta ccagtggaat 480
gatgacaggt gtaacatgaa gcacaattat atttgcaagt atgaaccaga gattaatcca 540
acagcccctg tagaaaagcc ttatcttaca aatcaaccag gagacaccca tcagaatgtg 600
gttgttactg aagcagtaaa ggaagaacaa aaactagtcc aaaccagtct acactgtgga 660
tttcaaagag taccagaaaa gaaagtggca tggaagtata ataactcatt gacttggttc 720
cagaattttg taattctgga tctgtataag gaatggcatc agaacaatag cttggaatgg 780
cttgaaatca caaaggatct gcaagatgaa ctgtaagctc ccccttgagg caaatattaa 840
agtaattttt atatgtctat tatttcattt aaagaatatg ctgtgctaat aatggagtga 900
gacatgctta ttttgctaaa ggatgcaccc aaacttcaaa cttcaagcaa atgaaatgga 960
caatgcagat aaagttgtta tcaacacgtc gggagtatgt gtgttagaag caattccttt 1020
tatttctttc acctttcata agttgttatc tagtcaatgt aatgtatatt gtattgaaat 1080
ttacagtgtg caaaagtatt ttacctttgc ataagtgttt gataaaaatg aactgttcta 1140
atatttattt ttatggcatc tcatttttca atacatgctc ttttgattaa agaaacttat 1200
tactgttgtc aactgaattc acacacacac aaatatagta ccatagaaaa agtttgtttt 1260
ctcgaaataa ttcatctttc agcttctctg cttttggtca atgtctagga aatctcttca 1320
gaaataagaa gctatttcat taagtgtgat ataaacctcc tcaaacattt tacttagagg 1380
caaggattgt ctaatttcaa ttgtgcaaga catgtgcctt ataattattt ttagcttaaa 1440
attaaacaga ttttgtaata atgtaacttt gttaataggt gcataaacac taatgcagtc 1500
aatttgaaca aaagaagtga catacacaat ataaatcata tgtcttcaca cgttgcctat 1560
ataatgagaa gcagctctct gagggttctg aaatcaatgt ggtccctctc ttgcccacta 1620
aacaaagatg gttgttcggg gtttgggatt gacactggag gcagatagtt gcaaagttag 1680
tctaaggttt ccctagctgt atttagcctc tgactatatt agtatacaaa gaggtcatgt 1740
ggttgagacc aggtgaatag tcactatcag tgtggagaca agcacagcac acagacattt 1800
taggaaggaa aggaactacg aaatcgtgtg aaaatgggtt ggaacccatc agtgatcgca 1860
tattcattga tgagggtttg cttgagatag aaaatggtgg ctcctttctg tcttatctcc 1920
tagtttcttc aatgcttacg ccttgttctt ctcaagagaa agttgtaact ctctggtctt 1980
catatgtccc tgtgctcctt ttaaccaaat aaagagttct tgtttctgaa gaa        2033

<210> 81
<211> 236
<212> PRT
<213> Homo sapiens

<400> 81
Met Ala Tyr Phe His Glu Leu Ser Ser Arg Val Ser Phe Gln Glu Ala
 1               5                  10                  15      
Arg Leu Ala Cys Glu Ser Glu Gly Gly Val Leu Leu Ser Leu Glu Asn
            20                  25                  30          
Glu Ala Glu Gln Lys Leu Ile Glu Ser Met Leu Gln Asn Leu Thr Lys
        35                  40                  45              
Pro Gly Thr Gly Ile Ser Asp Gly Asp Phe Trp Ile Gly Leu Trp Arg
    50                  55                  60                  
Asn Gly Asp Gly Gln Thr Ser Gly Ala Cys Pro Asp Leu Tyr Gln Trp
65                  70                  75                  80  
Ser Asp Gly Ser Asn Ser Gln Tyr Arg Asn Trp Tyr Thr Asp Glu Pro
                85                  90                  95      
Ser Cys Gly Ser Glu Lys Cys Val Val Met Tyr His Gln Pro Thr Ala
            100                 105                 110         
Asn Pro Gly Leu Gly Gly Pro Tyr Leu Tyr Gln Trp Asn Asp Asp Arg
        115                 120                 125             
Cys Asn Met Lys His Asn Tyr Ile Cys Lys Tyr Glu Pro Glu Ile Asn
    130                 135                 140                 
Pro Thr Ala Pro Val Glu Lys Pro Tyr Leu Thr Asn Gln Pro Gly Asp
145                 150                 155                 160 
Thr His Gln Asn Val Val Val Thr Glu Ala Val Lys Glu Glu Gln Lys
                165                 170                 175     
Leu Val Gln Thr Ser Leu His Cys Gly Phe Gln Arg Val Pro Glu Lys
            180                 185                 190         
Lys Val Ala Trp Lys Tyr Asn Asn Ser Leu Thr Trp Phe Gln Asn Phe
        195                 200                 205             
Val Ile Leu Asp Leu Tyr Lys Glu Trp His Gln Asn Asn Ser Leu Glu
    210                 215                 220                 
Trp Leu Glu Ile Thr Lys Asp Leu Gln Asp Glu Leu
225                 230                 235     


<210> 82
<211> 170
<212> PRT
<213> Homo sapiens

<400> 82
Met Ala Tyr Phe His Glu Leu Ser Ser Arg Val Ser Phe Gln Glu Ala
 1               5                  10                  15      
Arg Leu Ala Cys Glu Ser Glu Gly Gly Val Leu Leu Ser Leu Glu Asn
            20                  25                  30          
Glu Ala Glu Gln Lys Leu Ile Glu Ser Met Leu Gln Asn Leu Thr Lys
        35                  40                  45              
Pro Gly Thr Gly Ile Ser Asp Gly Asp Phe Trp Ile Gly Leu Trp Arg
    50                  55                  60                  
Asn Gly Asp Gly Gln Thr Ser Gly Ala Cys Pro Asp Leu Tyr Gln Trp
65                  70                  75                  80  
Ser Asp Gly Ser Asn Ser Gln Tyr Arg Asn Trp Tyr Thr Asp Glu Pro
                85                  90                  95      
Ser Cys Gly Ser Glu Lys Cys Val Val Met Tyr His Gln Pro Thr Ala
            100                 105                 110         
Asn Pro Gly Leu Gly Gly Pro Tyr Leu Tyr Gln Trp Asn Asp Asp Arg
        115                 120                 125             
Cys Asn Met Lys His Asn Tyr Ile Cys Lys Tyr Glu Pro Glu Ile Asn
    130                 135                 140                 
Pro Thr Ala Pro Val Glu Lys Pro Tyr Leu Thr Asn Gln Pro Gly Asp
145                 150                 155                 160 
Thr His Gln Asn Val Val Val Thr Glu Ala
                165                 170 


<210> 83
<211> 236
<212> PRT
<213> Homo sapiens

<400> 83
Met Ala Tyr Phe His Glu Leu Ser Ser Arg Val Ser Phe Gln Glu Ala
 1               5                  10                  15      
Arg Leu Ala Cys Glu Ser Glu Gly Gly Val Leu Leu Ser Leu Glu Asn
            20                  25                  30          
Glu Ala Glu Gln Lys Leu Ile Glu Ser Met Leu Gln Asn Leu Thr Lys
        35                  40                  45              
Pro Gly Thr Gly Ile Ser Asp Gly Asp Phe Trp Ile Gly Leu Trp Arg
    50                  55                  60                  
Asn Gly Asp Gly Gln Thr Ser Gly Ala Cys Pro Asp Leu Tyr Gln Trp
65                  70                  75                  80  
Ser Asp Gly Ser Asn Ser Gln Tyr Arg Asn Trp Tyr Thr Asp Glu Pro
                85                  90                  95      
Ser Cys Gly Ser Glu Lys Cys Val Val Met Tyr His Gln Pro Thr Ala
            100                 105                 110         
Asn Pro Gly Leu Gly Gly Pro Tyr Leu Tyr Gln Trp Asn Asp Asp Arg
        115                 120                 125             
Cys Asn Met Lys His Asn Tyr Ile Cys Lys Tyr Glu Pro Glu Ile Asn
    130                 135                 140                 
Pro Thr Ala Pro Val Glu Lys Pro Tyr Leu Thr Asn Gln Pro Gly Asp
145                 150                 155                 160 
Thr His Gln Asn Val Val Val Thr Glu Ala Val Lys Glu Glu Gln Lys
                165                 170                 175     
Leu Val Gln Thr Ser Leu His Cys Gly Phe Gln Arg Val Pro Glu Lys
            180                 185                 190         

Lys Val Ala Trp Lys Tyr Asn Asn Ser Leu Thr Trp Phe Gln Asn Phe
        195                 200                 205             
Val Ile Leu Asp Leu Tyr Lys Glu Trp His Gln Asn Asn Ser Leu Glu
    210                 215                 220                 
Trp Leu Glu Ile Thr Lys Asp Leu Gln Asp Glu Leu
225                 230                 235     

